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Wendy Wieland-Alter
Researcher at Dartmouth–Hitchcock Medical Center
Publications - 37
Citations - 1245
Wendy Wieland-Alter is an academic researcher from Dartmouth–Hitchcock Medical Center. The author has contributed to research in topics: Antibody & Poliovirus. The author has an hindex of 18, co-authored 34 publications receiving 882 citations. Previous affiliations of Wendy Wieland-Alter include Dartmouth College & Muhimbili University of Health and Allied Sciences.
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Journal ArticleDOI
Human seminal plasma fosters CD4(+) regulatory T-cell phenotype and transforming growth factor-β1 expression.
TL;DR: Semen mediates expansion of CD4+ regulatory T cells (Treg) in the murine female reproductive tract and the impact of semen on Treg in humans remains unclear.
Posted ContentDOI
SARS-CoV-2 antibody signatures robustly predict diverse antiviral functions relevant for convalescent plasma therapy
Harini Natarajan,Andrew R. Crowley,Savannah E. Butler,Shiwei Xu,Joshua A. Weiner,Evan M. Bloch,Kirsten Littlefield,Wendy Wieland-Alter,Ruth I. Connor,Peter F. Wright,Sarah E. Benner,Tania S. Bonny,Oliver Laeyendecker,Oliver Laeyendecker,David J. Sullivan,Shmuel Shoham,Thomas C. Quinn,Thomas C. Quinn,Larman Harry B,Arturo Casadevall,Andrew Pekosz,Andrew D. Redd,Andrew D. Redd,Aaron A.R. Tobian,Margaret E. Ackerman +24 more
TL;DR: This study functionally and phenotypically profiled plasma from eligible convalescent donors and suggested that high-throughput profiling could be used to screen donors and plasma may provide benefits beyond neutralization.
Journal ArticleDOI
A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa
Rafal S. Sobota,Rafal S. Sobota,Catherine M. Stein,Nuri Kodaman,Nuri Kodaman,Nuri Kodaman,Isaac Maro,Wendy Wieland-Alter,Robert P. Igo,Albert Magohe,La Shaunda L. Malone,Keith A. Chervenak,Noemi B. Hall,Mecky Matee,Harriet Mayanja-Kizza,Harriet Mayanja-Kizza,Moses Joloba,Moses Joloba,Jason H. Moore,Jason H. Moore,William K. Scott,Timothy Lahey,W. Henry Boom,C. Fordham von Reyn,Scott M. Williams,Scott M. Williams,Giorgio Sirugo +26 more
TL;DR: The results indicate that studying uninfected, HIV-positive participants with extensive exposure increases the power to detect associations in complex infectious disease.
Journal ArticleDOI
Intestinal Immune Responses to Type 2 Oral Polio Vaccine (OPV) Challenge in Infants Previously Immunized With Bivalent OPV and Either High-Dose or Standard Inactivated Polio Vaccine
Elizabeth B. Brickley,Carolyn B. Strauch,Wendy Wieland-Alter,Ruth I. Connor,Shu Lin,Joshua A. Weiner,Margaret E. Ackerman,Minetaro Arita,M. Steven Oberste,William C. Weldon,Xavier Sáez-Llorens,Ananda S Bandyopadhyay,Peter F. Wright +12 more
TL;DR: These results from a 2014 phase 2 clinical trial in Panamanian infants suggest that high-dose inactivated polio vaccines are largely ineffective at inducing levels of intestinal immune responses requisite to control poliovirus shedding.
Journal ArticleDOI
DAR-901 vaccine for the prevention of infection with Mycobacterium tuberculosis among BCG-immunized adolescents in Tanzania: A randomized controlled, double-blind phase 2b trial.
Patricia Munseri,Jamila Said,Maryam Amour,Albert Magohe,Mecky Matee,Christiaan A. Rees,Todd A. MacKenzie,Susan Tvaroha,Chris Bailey-Kellogg,Isaac Maro,Wendy Wieland-Alter,Lisa V. Adams,C. Robert Horsburgh,Keiko Nakamura,Robert D. Arbeit,Kisali Pallangyo,C. Fordham von Reyn +16 more
TL;DR: DAR-901 recipients with IGRA conversion demonstrated enhanced immune responses to ESAT-6 and a three-dose series of 1 mg DAR-901 was safe and well-tolerated but did not prevent initial or persistent IGRA Conversion.