Wenqing Li

TL;DR: It is shown that adoptive transfer of macrophages containing antimicrobial peptides linked to cathepsin B in the lysosomes can be applied for the treatment of multidrug-resistant bacteria-induced sepsis in mice with immunosuppression.

TL;DR: This study investigated a series of conditions for the long-term storage of LLNs with encapsulation of mRNA, and found that the addition with 5% sucrose or trehalose to LLNs could remain their mRNA delivery efficiency for at least three months in the liquid nitrogen storage condition.

TL;DR: A ratiometric fluorescent probe effectively captured endogenous HClO in the lungs of a lipopolysaccharide (LPS)-induced lung inflammation mouse model after intravenous administration.

TL;DR: This review summarizes the key elements of ADCs and highlights recent advances ofADCs, as well as important lessons learned from clinical data, and future directions.

TL;DR: A series of lipid-like nanomaterials (LLNs), named functionalized TT derivatives (FTT), are constructed for mRNA-based therapeutic applications in vivo, and FTT5 LLNs demonstrated high percentage of base editing on PCSK9 in vivo at a low dose of base editor mRNA and single guide RNA.