K
Katarina Le Blanc
Researcher at Karolinska University Hospital
Publications - 119
Citations - 19442
Katarina Le Blanc is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Mesenchymal stem cell & Transplantation. The author has an hindex of 55, co-authored 119 publications receiving 17432 citations. Previous affiliations of Katarina Le Blanc include Karolinska Institutet & Boston Medical Center.
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Journal ArticleDOI
Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells
Katarina Le Blanc,Ida Rasmusson,Berit Sundberg,Cecilia Götherström,Moustapha Hassan,Mehmet Uzunel,Olle Ringdén +6 more
TL;DR: It is postulate that mesenchymal stem cells have a potent immunosuppressive effect in vivo and are transplanted in a patient with severe treatment-resistant grade IV acute graft-versus-host disease of the gut and liver.
Journal ArticleDOI
Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study.
Katarina Le Blanc,Francesco Frassoni,Lynne M. Ball,Franco Locatelli,Helene Roelofs,Ian D. Lewis,Edoardo Lanino,Berit Sundberg,Maria Ester Bernardo,Mats Remberger,Giorgio Dini,R. Maarten Egeler,Andrea Bacigalupo,Willem E. Fibbe,Olle Ringdén +14 more
TL;DR: Infusion of mesenchymal stem cells expanded in vitro, irrespective of the donor, might be an effective therapy for patients with steroid-resistant, acute GVHD.
Journal ArticleDOI
HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells.
TL;DR: Undifferentiated and differentiated MSC do not elicit alloreactive lymphocyte proliferative responses and modulate immune responses, and the findings support that MSC can be transplantable between HLA-incompatible individuals.
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Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
Oscar P. B. Wiklander,Joel Z. Nordin,Aisling J. O’Loughlin,Ylva Gustafsson,Giulia Corso,Imre Mäger,Pieter Vader,Yi Lee,Helena Sork,Yiqi Seow,Nina Heldring,Lydia Alvarez-Erviti,C. I. Edvard Smith,Katarina Le Blanc,Paolo Macchiarini,Philipp Jungebluth,Matthew J.A. Wood,Samir El Andaloussi +17 more
TL;DR: This is the first extensive biodistribution investigation of EVs comparing the impact of several different variables, the results of which have implications for the design and feasibility of therapeutic studies using EVs.
Journal ArticleDOI
Multipotent mesenchymal stromal cells and the innate immune system
TL;DR: It is important to study the crosstalk between MSCs and innate immunity, which ranges from the bone marrow niche to injured tissue, and to identify components of the innate immune system also have a key role.