D
David W. Self
Researcher at University of Texas Southwestern Medical Center
Publications - 94
Citations - 15592
David W. Self is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Nucleus accumbens & Dopamine receptor. The author has an hindex of 54, co-authored 94 publications receiving 14649 citations. Previous affiliations of David W. Self include Yale University & University of California, Irvine.
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Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
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Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Vaishnav Krishnan,Ming-Hu Han,Danielle Graham,Olivier Berton,William Renthal,Scott J. Russo,Quincey LaPlant,Ami Graham,Michael Lutter,Diane C. Lagace,Subroto Ghose,Robin Reister,Paul Tannous,Thomas A. Green,Rachael L. Neve,Sumana Chakravarty,Arvind Kumar,Amelia J. Eisch,David W. Self,Francis S. Lee,Carol A. Tamminga,Donald C. Cooper,Howard K. Gershenfeld,Eric J. Nestler +23 more
TL;DR: It is shown that molecular recapitulations of three prototypical adaptations associated with the unsusceptible phenotype are each sufficient to promote resistant behavior and validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance.
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Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum
Arvind Kumar,Kwang H. Choi,William Renthal,Nadia M. Tsankova,David E. H. Theobald,Hoang Trang Truong,Scott J. Russo,Quincey LaPlant,Teresa S. Sasaki,Kimberly N. Whistler,Rachael L. Neve,David W. Self,Eric J. Nestler +12 more
TL;DR: It is shown that cocaine induces specific histone modifications at different gene promoters in striatum, a major neural substrate for cocaine's behavioral effects, and chromatin remodeling is an important regulatory mechanism underlying cocaine-induced neural and behavioral plasticity.
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Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Max B. Kelz,Jingshan Chen,William A. Carlezon,William A. Carlezon,Kim Whisler,Lauren Gilden,Alison M. Beckmann,Cathy Steffen,Ya-Jun Zhang,Louis A. Marotti,David W. Self,Tatiana Tkatch,Gytis Baranauskas,D. James Surmeier,Rachael L. Neve,Ronald S. Duman,Marina R. Picciotto,Eric J. Nestler +17 more
TL;DR: It is shown that ΔFosB expression increases the responsiveness of an animal to the rewarding and locomotor-activating effects of cocaine, which supports a model in which Δ FosB, by altering gene expression, enhances sensitivity to cocaine and may thereby contribute to cocaine addiction.
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Opiates inhibit neurogenesis in the adult rat hippocampus.
TL;DR: The findings suggest that opiate regulation of neurogenesis in the adult rat hippocampus may be one mechanism by which drug exposure influences hippocampal function.