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William A. Flavahan
Researcher at Harvard University
Publications - 35
Citations - 5545
William A. Flavahan is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer stem cell & Stem cell. The author has an hindex of 25, co-authored 32 publications receiving 4163 citations. Previous affiliations of William A. Flavahan include Case Western Reserve University & Cleveland Clinic.
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Journal ArticleDOI
Insulator dysfunction and oncogene activation in IDH mutant gliomas
William A. Flavahan,Yotam Drier,Yotam Drier,Yotam Drier,Brian B. Liau,Brian B. Liau,Brian B. Liau,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Andrew S. Venteicher,Andrew S. Venteicher,Anat Stemmer-Rachamimov,Mario L. Suvà,Mario L. Suvà,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +17 more
TL;DR: Human IDH mutant gliomas exhibit hypermethylation at cohesin and CCCTC-binding factor (CTCF)-binding sites, compromising binding of this methylation-sensitive insulator protein, and manifest a CpG island methylator phenotype (G-CIMP), although the functional importance of this altered epigenetic state remains unclear.
Journal ArticleDOI
Epigenetic plasticity and the hallmarks of cancer
TL;DR: It is proposed that chromatin and epigenetic aberrations have the potential to confer on cells the full range of oncogenic properties represented in the classic “hallmarks” depiction of cancer, and it is suggested that genetic, environmental, and metabolic factors can make chromatin aberrantly permissive or restrictive.
Journal ArticleDOI
Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
Wenchao Zhou,Susan Q. Ke,Zhi Huang,William A. Flavahan,Xiaoguang Fang,Jeremy Paul,Ling Wu,Andrew E. Sloan,Roger E. McLendon,Xiaoxia Li,Jeremy N. Rich,Shideng Bao +11 more
TL;DR: It is demonstrated that GSCs secrete periostin (POSTN) to recruit TAMs and found that TAMs in GBMs are not brain-resident microglia, but mainly monocyte-derived macrophages from peripheral blood.
Journal ArticleDOI
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
William A. Flavahan,Qiulian Wu,Masahiro Hitomi,Nasiha Rahim,Youngmi Kim,Andrew E. Sloan,Robert J. Weil,Ichiro Nakano,Jann N. Sarkaria,Brett W. Stringer,Bryan W. Day,Meizhang Li,Justin D. Lathia,Justin D. Lathia,Jeremy N. Rich,Jeremy N. Rich,Anita B. Hjelmeland,Anita B. Hjelmeland +17 more
TL;DR: It is reported that nutrient restriction contributes to tumor progression by enriching for brain tumor initiating cells ( BTICs) owing to preferential BTIC survival and to adaptation of non-BTICs through acquisition of BTIC features.
Journal ArticleDOI
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
Brian B. Liau,Brian B. Liau,Cem Sievers,Cem Sievers,Laura Donohue,Laura Donohue,Shawn M. Gillespie,Shawn M. Gillespie,William A. Flavahan,William A. Flavahan,Tyler E. Miller,Tyler E. Miller,Andrew S. Venteicher,Andrew S. Venteicher,Christine Hebert,Christine Hebert,Christopher D. Carey,Scott J. Rodig,Sarah J. Shareef,Sarah J. Shareef,Fadi J. Najm,Fadi J. Najm,Peter van Galen,Peter van Galen,Hiroaki Wakimoto,Daniel P. Cahill,Jeremy N. Rich,Jeremy N. Rich,Jon C. Aster,Mario L. Suvà,Mario L. Suvà,Anoop P. Patel,Anoop P. Patel,Bradley E. Bernstein,Bradley E. Bernstein +34 more
TL;DR: It is shown that GSCs can reversibly transition to a slow-cycling, persistent state in response to targeted kinase inhibitors, illustrating how cancer cells may hijack aspects of native developmental programs for deranged proliferation, adaptation, and tolerance.