C
Christopher D. Carey
Researcher at Newcastle University
Publications - 26
Citations - 1543
Christopher D. Carey is an academic researcher from Newcastle University. The author has contributed to research in topics: Lymphoma & Jet (fluid). The author has an hindex of 11, co-authored 24 publications receiving 974 citations. Previous affiliations of Christopher D. Carey include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
Brian B. Liau,Brian B. Liau,Cem Sievers,Cem Sievers,Laura Donohue,Laura Donohue,Shawn M. Gillespie,Shawn M. Gillespie,William A. Flavahan,William A. Flavahan,Tyler E. Miller,Tyler E. Miller,Andrew S. Venteicher,Andrew S. Venteicher,Christine Hebert,Christine Hebert,Christopher D. Carey,Scott J. Rodig,Sarah J. Shareef,Sarah J. Shareef,Fadi J. Najm,Fadi J. Najm,Peter van Galen,Peter van Galen,Hiroaki Wakimoto,Daniel P. Cahill,Jeremy N. Rich,Jeremy N. Rich,Jon C. Aster,Mario L. Suvà,Mario L. Suvà,Anoop P. Patel,Anoop P. Patel,Bradley E. Bernstein,Bradley E. Bernstein +34 more
TL;DR: It is shown that GSCs can reversibly transition to a slow-cycling, persistent state in response to targeted kinase inhibitors, illustrating how cancer cells may hijack aspects of native developmental programs for deranged proliferation, adaptation, and tolerance.
Journal ArticleDOI
Topological analysis reveals a PD-L1-associated microenvironmental niche for Reed-Sternberg cells in Hodgkin lymphoma
Christopher D. Carey,Christopher D. Carey,Daniel Gusenleitner,Mikel Lipschitz,Margaretha G.M. Roemer,Margaretha G.M. Roemer,Edward C. Stack,Evisa Gjini,Xihao Hu,Robert A. Redd,Gordon J. Freeman,Donna Neuberg,F. Stephen Hodi,Xiaole Shirley Liu,Margaret A. Shipp,Scott J. Rodig +15 more
TL;DR: A unique topology of cHL is defined in which PD-L1+ TAMs surround HRS cells and implicate CD4+ T cells as a target of PD-1 blockade.
Journal ArticleDOI
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma
Yotam Drier,Yotam Drier,Yotam Drier,Matthew J. Cotton,Matthew J. Cotton,Matthew J. Cotton,Kaylyn E. Williamson,Kaylyn E. Williamson,Kaylyn E. Williamson,Shawn M. Gillespie,Shawn M. Gillespie,Shawn M. Gillespie,Russell J.H. Ryan,Russell J.H. Ryan,Russell J.H. Ryan,Michael J. Kluk,Christopher D. Carey,Scott J. Rodig,Lynette M. Sholl,A. Afrogheh,William C. Faquin,Lurdes Queimado,Jun Qi,Michael J. Wick,Adel K. El-Naggar,James E. Bradner,James E. Bradner,Christopher A. Moskaluk,Jon C. Aster,Birgit Knoechel,Birgit Knoechel,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +33 more
TL;DR: This study identifies super-enhancer translocations that drive MYB expression and provides insight into downstream MYB functions in alternate ACC lineages.
Journal ArticleDOI
Developmental cell programs are co-opted in inflammatory skin disease
Gary Reynolds,Peter Vegh,James Fletcher,Elizabeth Poyner,Emily Stephenson,Issac Goh,Rachel A. Botting,Ni Huang,Bayanne Olabi,Bayanne Olabi,Anna Dubois,David Dixon,Kile Green,Daniel Maunder,Justin Engelbert,Mirjana Efremova,Krzysztof Polanski,Laura Jardine,C Jones,Thomas Ness,Dave Horsfall,Jim McGrath,Christopher D. Carey,Dorin-Mirel Popescu,Simone Webb,Xiao-Nong Wang,Ben Sayer,Jong-Eun Park,Victor A. Negri,Daria Belokhvostova,Magnus D. Lynch,David McDonald,Andrew Filby,Tzachi Hagai,Kerstin B. Meyer,A. Husain,Jonathan Coxhead,Roser Vento-Tormo,Sam Behjati,Sam Behjati,Steven Lisgo,Alexandra-Chloé Villani,Alexandra-Chloé Villani,Jaume Bacardit,Philip H. Jones,Philip H. Jones,Edel A. O'Toole,Graham S. Ogg,Neil Rajan,Nick J. Reynolds,Sarah A. Teichmann,Sarah A. Teichmann,Fiona M. Watt,Muzlifah Haniffa,Muzlifah Haniffa +54 more
TL;DR: In this paper, the transcriptomes of more than 500,000 single cells from developing human fetal skin, healthy adult skin, and adult skin with atopic dermatitis and psoriasis were compared across development, homeostasis, and disease.
Journal ArticleDOI
Classical Hodgkin Lymphoma with Reduced β2M/MHC Class I Expression Is Associated with Inferior Outcome Independent of 9p24.1 Status
Margaretha G.M. Roemer,Margaretha G.M. Roemer,Ranjana H. Advani,Robert A. Redd,Geraldine S. Pinkus,Yasodha Natkunam,Azra H. Ligon,Courtney Connelly,Christine Pak,Christopher D. Carey,Sarah E. Daadi,Bjoern Chapuy,Daphne de Jong,Richard T. Hoppe,Donna Neuberg,Margaret A. Shipp,Scott J. Rodig +16 more
TL;DR: Results suggest that MHC class I–mediated antigen presentation by HRS cells is an important component of the biological response to standard chemo/radiotherapy in classical Hodgkin lymphoma.