J
Justin D. Lathia
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 301
Citations - 19033
Justin D. Lathia is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Cancer stem cell & Stem cell. The author has an hindex of 59, co-authored 247 publications receiving 15245 citations. Previous affiliations of Justin D. Lathia include Cleveland Clinic & Duke University.
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Journal ArticleDOI
Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
Zhizhong Li,Shideng Bao,Shideng Bao,Qiulian Wu,Qiulian Wu,Hui Wang,Christine E. Eyler,Sith Sathornsumetee,Qing Shi,Yiting Cao,Justin D. Lathia,Justin D. Lathia,Roger E. McLendon,Anita B. Hjelmeland,Anita B. Hjelmeland,Jeremy N. Rich +15 more
TL;DR: It is demonstrated that hypoxia-inducible factor HIF2alpha and multiple HIF-regulated genes are preferentially expressed in GSCs in comparison to non-stem tumor cells and normal neural progenitors.
Journal ArticleDOI
Cancer stem cells in glioblastoma
Justin D. Lathia,Justin D. Lathia,Stephen C. Mack,Erin E. Mulkearns-Hubert,Claudia L.L. Valentim,Jeremy N. Rich,Jeremy N. Rich +6 more
TL;DR: To fulfill the future goal of developing novel therapies to collapse CSC dynamics, drawing parallels to other normal and pathological states that are highly interactive with their microenvironments and that use developmental signaling pathways will be beneficial.
Journal ArticleDOI
Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth
Lin Cheng,Zhi Huang,Wenchao Zhou,Qiulian Wu,Shannon Donnola,James K. Liu,Xiaoguang Fang,Andrew E. Sloan,Yubin Mao,Justin D. Lathia,Wang Min,Roger E. McLendon,Jeremy N. Rich,Shideng Bao +13 more
TL;DR: It is shown that GSCs give rise to pericytes to support vessel function and tumor growth, and therapeutic targeting of GSC-derived pericyts may effectively block tumor progression and improve antiangiogenic therapy.
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Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Sung-Chun Tang,Thiruma V. Arumugam,Thiruma V. Arumugam,Xiangru Xu,Aiwu Cheng,Mohamed R. Mughal,Dong-Gyu Jo,Dong-Gyu Jo,Justin D. Lathia,Dominic A. Siler,Srinivasulu Chigurupati,Xin Ouyang,Tim Magnus,Tim Magnus,Simonetta Camandola,Mark P. Mattson,Mark P. Mattson +16 more
TL;DR: It is reported that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-γ stimulation and energy deprivation, establishing a proapoptotic signaling pathway for TLR1 and -3 in neurons that may render them vulnerable to ischemic death.
Journal ArticleDOI
Integrin Alpha 6 regulates glioblastoma stem cells
Justin D. Lathia,Joseph J. Gallagher,John M. Heddleston,Jialiang Wang,Christine E. Eyler,Christine E. Eyler,Jennifer MacSwords,Qiulian Wu,Amit Vasanji,Roger E. McLendon,Anita B. Hjelmeland,Jeremy N. Rich +11 more
TL;DR: Evidence is provided that GSCs express high levels of integrin alpha6, which can serve not only as an enrichment marker but also as a promising antiglioblastoma therapy, and this work identified integrinalpha6 as a candidate for anti-tumor therapy.