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William E. Seifert
Researcher at University of Texas at Austin
Publications - 35
Citations - 1428
William E. Seifert is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Homovanillic acid & Dopamine. The author has an hindex of 16, co-authored 35 publications receiving 1394 citations. Previous affiliations of William E. Seifert include University of Texas Health Science Center at Houston & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Metabolism of the Lipid Peroxidation Product, 4-Hydroxy-trans-2-nonenal, in Isolated Perfused Rat Heart
Sanjay K. Srivastava,Animesh Chandra,Lifei Wang,William E. Seifert,Beverly B. DaGue,Naseem H. Ansari,Satish K. Srivastava,Aruni Bhatnagar +7 more
TL;DR: The results show that the major metabolic transformations of HNE in rat heart involve conjugation with glutathione and oxidation to 4-hydroxy-2-nonenoic acid.
Journal ArticleDOI
Biogenic amine metabolism in tourette syndrome
Ian J. Butler,Ian J. Butler,Stephen H. Koslow,Stephen H. Koslow,Stephen H. Koslow,William E. Seifert,William E. Seifert,Richard M. Caprioli,Richard M. Caprioli,Richard M. Caprioli,Harvey S. Singer,Harvey S. Singer +11 more
TL;DR: An underlying disorder of dopamine and serotonin metabolism in Tourette syndrome is suggested, as both baseline and accumulated levels of HVA after probenecid were decreased.
Journal ArticleDOI
Dopaminergic dysfunction in tourette syndrome
TL;DR: The hypothesis that Tourette syndrome may result form a supersensitivity of dopaminergic receptors is supported by the results of a prospective clinical and biochemical study.
Journal ArticleDOI
Curcumin–glutathione interactions and the role of human glutathione S-transferase P1-1
Sanjay Awasthi,Utpal Pandya,Sharad S. Singhal,James T. Lin,Varatharasa Thiviyanathan,William E. Seifert,Yogesh C. Awasthi,Ghulam Ansari +7 more
TL;DR: The presence of recombinant human glutathione S-transferase(GST)P1-1 significantly accelerated the initial rate of GSH-mediated consumption of curcumin in 10 mM potassium phosphate, pH 7.0, and 1 mM GSH and was shown to catalyze the reverse reaction leading to the formation ofCurcumin from GSH adducts of FMK and FAL.
Journal ArticleDOI
Age effect on dopamine and serotonin metabolite levels in cerebrospinal fluid.
TL;DR: Patients had various specific disorders of the nervous system, though patients with movement disorders and biochemical defects known to affect the neurotransmitter systems examined in this study were specifically avoided.