William K. Holloman

TL;DR: The discovery of the secreted protein gene clusters and the functional demonstration of their decisive role in the infection process illuminate previously unknown mechanisms of pathogenicity operating in biotrophic fungi.

TL;DR: A chimeric oligonucleotide composed of DNA and modified RNA residues was used to direct correction of the mutation in the hemoglobin βS allele and there was a detectable level of gene conversion of the mutant allele to the normal sequence.

TL;DR: It is shown that a full-length BRCA2 homologue (Brh2) stimulates Rad51-mediated recombination at substoichiometric concentrations relative to Rad51, establishing a BRC a2 function in RAD51- mediated DSB repair and explaining the loss of this repair capacity in BRCa2-associated cancers.

TL;DR: DNA fragments that function as autonomously replicating sequences (ARSs) have been isolated from Ustilago maydis and when inserted into an integrative transforming vector, the fragments increased the frequency of U. maydis transformation several-thousandfold.

TL;DR: A model in which BLM selectively dissociates recombination intermediates likely to be unfavorable for recombination-promoted replication is proposed and found that BLM preferentially melts those D-loops that are formed more favorably by the strand exchange protein Rad51, but whose polarity could be less favorable for enabling restoration of an active replication fork.