J
James W. Kronstad
Researcher at University of British Columbia
Publications - 178
Citations - 12422
James W. Kronstad is an academic researcher from University of British Columbia. The author has contributed to research in topics: Cryptococcus neoformans & Ustilago. The author has an hindex of 56, co-authored 170 publications receiving 11235 citations. Previous affiliations of James W. Kronstad include University of Washington & ZymoGenetics.
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Journal ArticleDOI
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
Jörg Kämper,Regine Kahmann,Michael Bölker,Li-Jun Ma,Thomas Brefort,Barry J. Saville,Barry J. Saville,Flora Banuett,James W. Kronstad,Scott E. Gold,Olaf Müller,Michael H. Perlin,Han A. B. Wösten,Ronald P. de Vries,Jose Ruiz-Herrera,Cristina G. Reynaga-Peña,Karen M. Snetselaar,Michael P. McCann,José Pérez-Martín,Michael Feldbrügge,Christoph W. Basse,Gero Steinberg,José I. Ibeas,William K. Holloman,Plinio Guzmán,Mark L. Farman,Jason E. Stajich,Rafael Sentandreu,Juan Manuel González-Prieto,John C. Kennell,Lazaro Molina,Jan Schirawski,Artemio Mendoza-Mendoza,Doris Greilinger,Karin Münch,Nicole Rössel,Mario Scherer,Miroslav Vranes,Oliver Ladendorf,Volker Vincon,Uta Fuchs,Björn Sandrock,Shaowu Meng,Eric C.H. Ho,Matt J. Cahill,Kylie J. Boyce,Jana Klose,Steven J. Klosterman,Heine J. Deelstra,Lucila Ortiz-Castellanos,Weixi Li,Patricia Sánchez-Alonso,Peter Schreier,Isolde Häuser-Hahn,Martin Vaupel,Edda Koopmann,Gabi Friedrich,Hartmut Voss,Thomas Schlüter,Jonathan Margolis,Darren Mark Platt,Candace Swimmer,Andreas Gnirke,Feng Chen,Valentina Vysotskaia,Gertrud Mannhaupt,Ulrich Güldener,Martin Münsterkötter,Dirk Haase,Matthias Oesterheld,Hans-Werner Mewes,Evan Mauceli,David DeCaprio,Claire M. Wade,Jonathan Butler,Sarah Young,David B. Jaffe,Sarah E. Calvo,Chad Nusbaum,James E. Galagan,Bruce W. Birren +80 more
TL;DR: The discovery of the secreted protein gene clusters and the functional demonstration of their decisive role in the infection process illuminate previously unknown mechanisms of pathogenicity operating in biotrophic fungi.
Journal ArticleDOI
The Genome of the Basidiomycetous Yeast and Human Pathogen Cryptococcus Neoformans
Brendan J. Loftus,Eula Fung,Paola Roncaglia,Don Rowley,Paolo Amedeo,Dan Bruno,Jessica Vamathevan,Molly Miranda,Iain J. Anderson,James A. Fraser,Jonathan E. Allen,Ian Bosdet,Michael R. Brent,Readman Chiu,Tamara L. Doering,Maureen J. Donlin,Cletus D'Souza,Deborah S. Fox,Deborah S. Fox,Viktoriya Grinberg,Jianmin Fu,Marilyn Fukushima,Brian J. Haas,James Huang,Guilhem Janbon,Steven J.M. Jones,Hean L. Koo,Martin Krzywinski,June Kwon-Chung,Klaus B. Lengeler,Klaus B. Lengeler,Rama Maiti,Marco A. Marra,Robert E. Marra,Robert E. Marra,Carrie Mathewson,Thomas G. Mitchell,Mihaela Pertea,Florenta R. Riggs,Steven L. Salzberg,Jacqueline E. Schein,Alla Shvartsbeyn,Heesun Shin,Martin Shumway,Charles A. Specht,Bernard B. Suh,Aaron Tenney,T. Utterback,Brian L. Wickes,Jennifer R. Wortman,Natasja Wye,James W. Kronstad,Jennifer K. Lodge,Joseph Heitman,Ronald W. Davis,Claire M. Fraser,Richard W. Hyman +56 more
TL;DR: Comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes, and the genome is rich in transposons, many of which cluster at candidate centromeric regions.
Journal ArticleDOI
Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens
Jun Xu,Charles Winston Saunders,Ping Hu,Raymond A. Grant,Teun Boekhout,Eiko E. Kuramae,James W. Kronstad,Yvonne M. DeAngelis,Nancy L. Reeder,Kevin Robert Johnstone,Meredith Leland,Angela Marie Fieno,William M. Begley,Yiping Sun,Martin P. Lacey,Tanuja Chaudhary,Thomas Keough,Lien Chu,Russell Sears,Bo Yuan,Thomas L. Dawson +20 more
TL;DR: The M. globosa genome sequence revealed the presence of mating-type genes, providing an indication that Malassezia may be capable of sex, and the importance of host-specific adaptation.
Journal ArticleDOI
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation
Guilhem Janbon,Kate L. Ormerod,Damien Paulet,Edmond J. Byrnes,Vikas Yadav,Gautam Chatterjee,Nandita Mullapudi,Chung-Chau Hon,R. Blake Billmyre,François Brunel,Yong Sun Bahn,Weidong Chen,Yuan Chen,Eve W. L. Chow,Jean Yves Coppée,Anna Floyd-Averette,Claude Gaillardin,Kimberly J. Gerik,Jonathan M. Goldberg,Sara Gonzalez-Hilarion,Sharvari Gujja,Joyce L. Hamlin,Yen-Ping Hsueh,Yen-Ping Hsueh,Giuseppe Ianiri,Steven J.M. Jones,Chinnappa D. Kodira,Lukasz Kozubowski,Woei Lam,Marco A. Marra,Larry D. Mesner,Piotr A. Mieczkowski,Frédérique Moyrand,Kirsten Nielsen,Kirsten Nielsen,Caroline Proux,Tristan Rossignol,Jacqueline E. Schein,Sheng Sun,Carolin Wollschlaeger,Ian A. Wood,Qiandong Zeng,Cécile Neuvéglise,Carol S. Newlon,John R. Perfect,Jennifer K. Lodge,Alexander Idnurm,Jason E. Stajich,Jason E. Stajich,James W. Kronstad,Kaustuv Sanyal,Joseph Heitman,James A. Fraser,Christina A. Cuomo,Fred S. Dietrich +54 more
TL;DR: The spectrum of mutations identified provides insights into the genetics underlying the micro-evolution of a laboratory strain, and identifies mutations involved in stress responses, mating efficiency, and virulence.
Journal ArticleDOI
The Case for Adopting the "Species Complex" Nomenclature for the Etiologic Agents of Cryptococcosis.
Kyung J. Kwon-Chung,John E. Bennett,Brian L. Wickes,Wieland Meyer,Christina A. Cuomo,Kurt R. Wollenburg,Tihana Bicanic,Elizabeth Castañeda,Yun C. Chang,Jianghan Chen,Massimo Cogliati,Françoise Dromer,David Ellis,Scott G. Filler,Matthew C. Fisher,Thomas S. Harrison,Steven M. Holland,Shigeru Kohno,James W. Kronstad,Márcia dos Santos Lazéra,Stuart M. Levitz,Michail S. Lionakis,Robin C. May,Popchai Ngamskulrongroj,Peter G. Pappas,John R. Perfect,Volker Rickerts,Tania C. Sorrell,Thomas J. Walsh,Peter R. Williamson,Jianping Xu,Adrian M. Zelazny,Arturo Casadevall +32 more
TL;DR: In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, it is recommended to use “Cryptococcus neoformans species complex” and “C. gattii speciescomplex” as a practical intermediate step, rather than creating more species.