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William Laine
Researcher at university of lille
Publications - 19
Citations - 677
William Laine is an academic researcher from university of lille. The author has contributed to research in topics: DNA & Topoisomerase. The author has an hindex of 12, co-authored 15 publications receiving 603 citations. Previous affiliations of William Laine include University of Santiago de Compostela & University of Alcalá.
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Journal ArticleDOI
Molecular determinants of topoisomerase I poisoning by lamellarins: comparison with camptothecin and structure-activity relationships.
Esther Marco,William Laine,Christelle Tardy,Amélie Lansiaux,Masatomo Iwao,Fumito Ishibashi,Christian Bailly,Federico Gago +7 more
TL;DR: The results show that the 20-OH and 8-OH of LMD can participate in hydrogen-bonding interactions with the side chains of Glu356 and Asn722, respectively, the latter being consistent with the finding that CEM/C2 cells, which are resistant to CPT, are cross-resistant to LMD.
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Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues
Christelle Tardy,Michael Facompré,William Laine,Brigitte Baldeyrou,Dolores Garcı́a-Gravalos,Andrés Francesch,Cristina Mateo,Alfredo Pastor,José A Jiménez,Ignacio Manzanares,Carmen Cuevas,Christian Bailly +11 more
TL;DR: The observed correlation between cytotoxicity and topoisomerase I inhibition strongly suggests that topoisomersase I-mediated DNA cleavage assays can be used as a guide to the development of superior analogues in this series.
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DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.
Marie-Hélène David-Cordonnier,Consuelo Gajate,Osvaldo Olmea,William Laine,Janis de la Iglesia-Vicente,Carlos Perez,Carmen Cuevas,Gabriel Otero,Ignacio Manzanares,Christian Bailly,Faustino Mollinedo +10 more
TL;DR: The data suggest that trabectedin interacts with an additional non-DNA target to raise an effective antitumor response, and that this interaction is favored through trabectionin-DNA complexes.
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Enantiospecific Recognition of DNA Sequences by a Proflavine Tröger Base
TL;DR: DNase I footprinting experiments demonstrate that the binding of the proflavine-based Tröger base is both enantio- and sequence-specific, and is the first experimental demonstration that acridine-type Tr Öger bases can be used for enantiospecific recognition of DNA sequences.
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Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptide.
Andrea Negri,Esther Marco,Verónica García-Hernández,Alberto Domingo,Antonio L. Llamas-Saiz,Silvia Porto-Sanda,Ricardo Riguera,William Laine,Marie-Hélène David-Cordonnier,Christian Bailly,Luis F. García-Fernández,Juan J. Vaquero,Federico Gago +12 more
TL;DR: X-ray diffraction analyses of orthorhombic crystals of this DNA-binding drug revealed arrays of docked pairs of staple-shaped molecules in which one pendent hydroxyquinoline chromophore from each cysteine-rich molecule appears intercalated between the two chromophores of a facing molecule.