W
William M. Watkins
Researcher at University of Oxford
Publications - 104
Citations - 7545
William M. Watkins is an academic researcher from University of Oxford. The author has contributed to research in topics: Malaria & Sulfadoxine. The author has an hindex of 47, co-authored 103 publications receiving 7368 citations. Previous affiliations of William M. Watkins include University of Liverpool & Kenya Medical Research Institute.
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Journal ArticleDOI
Averting a malaria disaster.
Nicholas J. White,François Nosten,Sornchai Looareesuwan,William M. Watkins,Kevin Marsh,Robert W. Snow,Gilbert Kokwaro,John H. Ouma,Tran Tinh Hien,Malcolm E. Molyneux,Malcolm E. Molyneux,Terrie E. Taylor,Terrie E. Taylor,Chris I. Newbold,TK Ruebush,M Danis,Brian Greenwood,Roy M. Anderson,Piero Olliaro +18 more
TL;DR: Pyrimethamine-sulphadoxine (PSD) is usually deployed as a successor to chloroquine, but resistance to PSD is increasing and a health calamity looms within the next few years.
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Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropteroate Synthase and Epidemiologic Patterns of Pyrimethamine-Sulfadoxine Use and Resistance
Christopher V. Plowe,Joseph F. Cortese,Abdoulaye A. Djimde,Okey C. Nwanyanwu,William M. Watkins,Peter A. Winstanley,Jose G. Estrada Franco,René Mollinedo,Juan Carlos Avila,Jose Luis Cespedes,Darrick Carter,Ogobara K. Doumbo +11 more
TL;DR: Identification of specific sets of mutations causing in vivo drug failure may lead to the development of molecular surveillance methods for pyrimethamine-sulfadoxine resistance.
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Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next?
Carol Hopkins Sibley,John E. Hyde,Paul F. G. Sims,Christopher V. Plowe,James G. Kublin,E.K. Mberu,Alan F. Cowman,Peter Winstanley,William M. Watkins,Alexis Nzila +9 more
TL;DR: The molecular mechanisms of resistance to chloroquine are reviewed, and how to extend the therapeutic life of antifolate drugs is discussed.
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Sequence Variation of the Hydroxymethyldihydropterin Pyrophosphokinase: Dihydropteroate Synthase Gene in Lines of the Human Malaria Parasite, Plasmodium falciparum, with Differing Resistance to Sulfadoxine
TL;DR: To investigate a possible genetic basis for clinical resistance to sulfa drugs, the complete H2Pte synthase domains from eleven isolates of P. falciparum with diverse geographical origins and levels of sulfadoxine resistance were sequenced.
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Life-threatening bacteraemia in HIV-1 seropositive adults admitted to hospital in Nairobi, Kenya.
Charles F. Gilks,R J Brindle,L S Otieno,P M Simani,R S Newnham,S M Bhatt,Godfrey Lule,G B Okelo,William M. Watkins,Peter G. Waiyaki +9 more
TL;DR: The findings suggest that non-opportunistic bacteria are important causes of morbidity and mortality in HIV-infected individuals in Africa.