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Alexis Nzila
Researcher at King Fahd University of Petroleum and Minerals
Publications - 102
Citations - 5086
Alexis Nzila is an academic researcher from King Fahd University of Petroleum and Minerals. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 36, co-authored 94 publications receiving 4438 citations. Previous affiliations of Alexis Nzila include John Radcliffe Hospital & Liverpool School of Tropical Medicine.
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Journal ArticleDOI
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing
Magnus Manske,Magnus Manske,Olivo Miotto,Olivo Miotto,Susana Campino,Susana Campino,Sarah Auburn,Sarah Auburn,Sarah Auburn,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Jacob Almagro-Garcia,Gareth Maslen,Gareth Maslen,John O'Brien,John O'Brien,Abdoulaye A. Djimde,Ogobara K. Doumbo,Issaka Zongo,Jean-Bosco Ouédraogo,Pascal Michon,Ivo Mueller,Peter Siba,Alexis Nzila,Steffen Borrmann,Steven M. Kiara,Kevin Marsh,Hongying Jiang,Xin-zhuan Su,Chanaki Amaratunga,Rick M. Fairhurst,Duong Socheat,François Nosten,François Nosten,Mallika Imwong,Nicholas J. White,Nicholas J. White,Mandy Sanders,Elisa Anastasi,Dan Alcock,Eleanor Drury,Samuel O. Oyola,Michael A. Quail,Daniel J. Turner,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Valentin Ruano-Rubio,Dushyanth Jyothi,Dushyanth Jyothi,Lucas Amenga-Etego,Lucas Amenga-Etego,Christina Hubbart,Anna E. Jeffreys,Kate Rowlands,Colin J. Sutherland,Cally Roper,Valentina D. Mangano,David Modiano,John C. Tan,Michael T. Ferdig,Alfred Amambua-Ngwa,David J. Conway,Shannon Takala-Harrison,Christopher V. Plowe,Julian C. Rayner,Kirk A. Rockett,Kirk A. Rockett,Kirk A. Rockett,Taane G. Clark,Taane G. Clark,Taane G. Clark,Chris I. Newbold,Chris I. Newbold,Matthew Berriman,Bronwyn MacInnis,Bronwyn MacInnis,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +78 more
TL;DR: Methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture are described.
Journal ArticleDOI
Pyrimethamine–sulfadoxine resistance in Plasmodium falciparum: what next?
Carol Hopkins Sibley,John E. Hyde,Paul F. G. Sims,Christopher V. Plowe,James G. Kublin,E.K. Mberu,Alan F. Cowman,Peter Winstanley,William M. Watkins,Alexis Nzila +9 more
TL;DR: The molecular mechanisms of resistance to chloroquine are reviewed, and how to extend the therapeutic life of antifolate drugs is discussed.
Journal ArticleDOI
Towards an Understanding of the Mechanism of Pyrimethamine-Sulfadoxine Resistance in Plasmodium falciparum: Genotyping of Dihydrofolate Reductase and Dihydropteroate Synthase of Kenyan Parasites
Alexis Nzila,Alexis Nzila,E. K. Mberu,E. K. Mberu,J. Sulo,H. Dayo,Peter Winstanley,Carol Hopkins Sibley,William M. Watkins,William M. Watkins +9 more
TL;DR: The results demonstrate that the triply mutated allele of DHFR with or without mutant DHPS alleles is associated with RI and RII resistance to PM-SD, and may be an operationally useful marker for predicting the effectiveness of PM- SD as a new malaria treatment.
Journal ArticleDOI
Polymorphisms in Plasmodium falciparum chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine
Meera Venkatesan,Nahla B Gadalla,Kasia Stepniewska,Prabin Dahal,Christian Nsanzabana,Clarissa Moriera,Ric N. Price,Andreas Mårtensson,Philip J. Rosenthal,Grant Dorsey,Colin J. Sutherland,Philippe J Guerin,Timothy M. E. Davis,Didier Menard,Ishag Adam,George O. Ademowo,Cesar Arze,Frederick N. Baliraine,Nicole Berens-Riha,Anders Björkman,Steffen Borrmann,Francesco Checchi,Meghna Desai,Mehul Dhorda,Abdoulaye Djimde,Badria B. El-Sayed,Teferi Eshetu,Frederick Eyase,Catherine O. Falade,Jean-François Faucher,Gabrielle Fröberg,Anastasia Grivoyannis,Sally Hamour,Sandrine Houzé,Jacob D. Johnson,Erasmus Kamugisha,Simon Kariuki,Jean-René Kiechel,Fred Kironde,Fred Kironde,Poul-Erik Kofoed,Jacques Lebras,Maja Malmberg,Maja Malmberg,Leah Mwai,Leah Mwai,Billy Ngasala,François Nosten,Samuel L. Nsobya,Alexis Nzila,Alexis Nzila,Mary C. Oguike,Sabina Dahlström Otienoburu,Bernhards Ogutu,Jean-Bosco Ouédraogo,Patrice Piola,Patrice Piola,Lars Rombo,Birgit Schramm,A. Fabrice Some,Julie Thwing,Johan Ursing,Rina P. M. Wong,Ahmed Zeynudin,Issaka Zongo,Christopher V. Plowe,Carol Hopkins Sibley,Carol Hopkins Sibley +67 more
TL;DR: Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine.
Journal ArticleDOI
Chlorproguanil-dapsone for treatment of drug-resistant falciparum malaria in Tanzania
Theonest K. Mutabingwa,Alexis Nzila,E.K. Mberu,Eunice Nduati,Peter Winstanley,Elizabeth Hills,William M. Watkins +6 more
TL;DR: Analysis of parasite dhfr and dhps before and after treatment supports the view that pyrimethamine-sulfadoxine resistance in this part of Africa is primarily due to parasites with three mutations in the dhfr domain.