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William R. Marrs
Researcher at University of Washington
Publications - 10
Citations - 873
William R. Marrs is an academic researcher from University of Washington. The author has contributed to research in topics: Cannabinoid receptor & ABHD6. The author has an hindex of 9, co-authored 10 publications receiving 799 citations. Previous affiliations of William R. Marrs include University of California, Los Angeles.
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Journal ArticleDOI
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors
William R. Marrs,Jacqueline L. Blankman,Eric A. Horne,Aurore Thomazeau,Yi Hsing Lin,Jonathan Coy,Ágnes L. Bodor,Giulio G. Muccioli,Sherry Shu Jung Hu,Grace Woodruff,Susan Fung,Mathieu Lafourcade,Jessica P. Alexander,Jonathan Z. Long,Weiwei Li,Cong Xu,Thomas Möller,Ken Mackie,Olivier J. Manzoni,Benjamin F. Cravatt,Nephi Stella +20 more
TL;DR: The results indicate that ABHD6 is a rate-limiting step of 2-AG signaling and is therefore a bona fide member of the endocannabinoid signaling system.
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ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.
Alipi Naydenov,Eric A. Horne,Christine S. Cheah,Katie Swinney,Ku-Lung Hsu,Jessica K. Cao,William R. Marrs,Jacqueline L. Blankman,Sarah Tu,Allison E. Cherry,Susan Fung,Andy Wen,Weiwei Li,Michael S. Saporito,Dana E. Selley,Benjamin F. Cravatt,John C. Oakley,Nephi Stella +17 more
TL;DR: It is shown that ABHD6 inhibition decreases pentylenetetrazole (PTZ)-induced generalized tonic-clonic and myoclonic seizure incidence and severity and may represent a novel antiepileptic strategy.
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The expression level of CB1 and CB2 receptors determines their efficacy at inducing apoptosis in astrocytomas
TL;DR: The high expression level of CB1 and CB2 receptors commonly found in malignant astrocytomas precludes the use of cannabinoids as therapeutics, unless AKT is concomitantly inhibited, or cannabinoids are applied at concentrations that bypassCB1 andCB2 receptors, yet still activate ERK1/2.
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Discovery-Based Science Education: Functional Genomic Dissection in Drosophila by Undergraduate Researchers
Jiong Chen,Gerald B. Call,Elsa Beyer,Christopher N.H. Bui,Albert Cespedes,Amy M. Chan,Jenny Chan,Stacy Chan,Akanksha Chhabra,Peter Dang,Artemis Deravanesian,Brenda Hermogeno,James Jen,Eunha Kim,Eric Lee,Gemma Lewis,Jamie L. Marshall,Kirsten Regalia,Farnaz Shadpour,Aram Shemmassian,Kristin Spivey,Maggie Wells,Joy Wu,Yuki Yamauchi,Amir Yavari,Anna L. Abrams,Amanda Abramson,Latiffe Amado,Jenny Anderson,Keenan Bashour,Elena Bibikova,Allen Bookatz,Sarah Brewer,Natalie Buu,Stephanie Calvillo,Joseph Cao,Aileen Chang,Daniel Chang,Yuli Chang,Yibing Chen,Joo Choi,Jeyling Chou,Sumit Datta,Ardy Davarifar,Poonam Desai,Jordan Fabrikant,Shahbaz Farnad,Katherine Fu,Eddie Garcia,Nick Garrone,Srpouhi Gasparyan,Phyllis Gayda,Chad Goffstein,Courtney Gonzalez,Mariam Guirguis,Ryan Hassid,Aria Hong,Julie Hong,Lindsay Hovestreydt,Charles Hu,Farid Jamshidian,Katrin Kahen,Linda Kao,Melissa M. Kelley,Thomas Kho,Sarah Kim,Yein Kim,Brian Kirkpatrick,Emil Kohan,Robert Kwak,Adam D. Langenbacher,Santino Laxamana,Christopher Lee,Janet Lee,So-Youn Lee,To Hang S Lee,Toni Lee,Sheila Lezcano,Henry Lin,Peter Lin,Julie Luu,Thanh Luu,William R. Marrs,Erin Marsh,Sarah Min,Tanya Minasian,Amit Misra,Miles Morimoto,Yasaman Moshfegh,Jessica Murray,Cynthia Nguyen,Kha Nguyen,Ernesto Nodado,Amanda O'Donahue,Ndidi Onugha,Nneka Orjiakor,Bhavin Padhiar,Mara Pavel-Dinu,Alex Pavlenko,Edwin Paz,Sarah Phaklides,Lephong Pham,Preethi Poulose,Russell Powell,Aya Pusic,Divi Ramola,Meghann Ribbens,Bassel Rifai,Desiree Rosselli,Manyak Saakyan,Pamela Saarikoski,Miriam Segura,Ramnik Singh,Vivek Singh,Emily Skinner,Daniel Solomin,Kosha Soneji,Erika Stageberg,Marina Stavchanskiy,Leena Tekchandani,Leo Thai,Jayantha Thiyanaratnam,Maurine Tong,Aneet Toor,Steve Tovar,Kelly Trangsrud,Wah-Yung Tsang,Marc Uemura,Mary Unkovic,Emily Vollmer,Emily Weiss,Damien Wood,Sophia Wu,Winston Wu,Qing Xu,Kevin Yackle,Will Yarosh,Laura Yee,George Yen,Grant Alkin,Sheryllene Go,Devon M Huff,Helena Minye,Eric Paul,Nikki Villarasa,Allison Milchanowski,Utpal Banerjee +146 more
TL;DR: The UCLA Undergraduate Consortium for Functional Genomics provides the answer to how to combine professional-quality research with discovery-based undergraduate education.
Journal ArticleDOI
Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats.
TL;DR: Data indicate that alpha-2 adrenoreceptors tonically inhibit PCP-induced deficits of spatial working memory, suggesting an important role for these receptors in cognitive deficits associated with NMDA receptor hypofunction.