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Wilma Wasco
Researcher at Harvard University
Publications - 70
Citations - 15503
Wilma Wasco is an academic researcher from Harvard University. The author has contributed to research in topics: Presenilin & Calsenilin. The author has an hindex of 35, co-authored 70 publications receiving 15060 citations. Previous affiliations of Wilma Wasco include United States Department of Veterans Affairs & Rockefeller University.
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Journal ArticleDOI
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
R. Sherrington,Evgeny I. Rogaev,Yan Liang,Ekaterina Rogaeva,G. Levesque,M. Ikeda,H. Chi,Chih-Ping Lin,Gavin Li,K. Holman,T. Tsuda,L. Mar,J. F. Foncin,Amalia C. Bruni,Mp Montesi,Sandro Sorbi,Innocenzo Rainero,Lorenzo Pinessi,L. Nee,Ilya Chumakov,Daniel A. Pollen,A. Brookes,Philippe Sanseau,R. Polinsky,Wilma Wasco,H. A. R. Da Silva,Jonathan L. Haines,Margaret A. Pericak-Vance,Rudolph E. Tanzi,A. D. Roses,Paul E. Fraser,Johanna M. Rommens,P. St. George-Hyslop +32 more
TL;DR: A minimal cosegregating region containing the AD3 gene is defined, and at least 19 different transcripts encoded within this region corresponds to a novel gene whose product is predicted to contain multiple transmembrane domains and resembles an integral membrane protein.
Journal ArticleDOI
Candidate gene for the chromosome 1 familial Alzheimer's disease locus
Ephrat Levy-Lahad,Wilma Wasco,Parvoneh Poorkaj,Donna M. Romano,Junko Oshima,Warren H. Pettingell,Chang En Yu,P. D. Jondro,Stephen D. Schmidt,Kai Wang,Annette C. Crowley,Ying-Hui Fu,Suzanne Y. Guénette,David J. Galas,Ellen Nemens,Ellen M. Wijsman,Thomas D. Bird,Gerard D. Schellenberg,Rudolph E. Tanzi +18 more
TL;DR: The presence of missense mutations in AD subjects in two highly similar genes strongly supports the hypothesis that mutations in both are pathogenic.
Journal ArticleDOI
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
D. Scheuner,Christopher B. Eckman,Christopher B. Eckman,Malene Jensen,X. Song,Martin Citron,Nobuhiro Suzuki,Thomas D. Bird,John Hardy,Mike Hutton,Walter A. Kukull,Eric Larson,Ephrat Levy-Lahad,Matti Viitanen,Elaine R. Peskind,Parvoneh Poorkaj,Gerard D. Schellenberg,Rudolph E. Tanzi,Wilma Wasco,Lars Lannfelt,Dennis J. Selkoe,Steven G. Younkin +21 more
TL;DR: The findings indicate that the FAD–linked mutations may all cause Alzheimer's disease by increasing the extracellular concentration of Aβ42(43), thereby fostering cerebral deposition of this highly amyloidogenic peptide.
Journal ArticleDOI
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.
Rudolph E. Tanzi,Konstantin Petrukhin,Igor P. Chernov,Jean-Luc Pellequer,Wilma Wasco,B Ross,Donna M. Romano,Enrico Parano,Lorenzo Pavone,Linda M. Brzustowicz +9 more
TL;DR: The predicted functional properties of the pWD gene together with its strong homology to Mc1, genetic mapping data and identification of four independent disease–specific mutations, provide convincing evidence that pWD is the Wilson disease gene.
Journal ArticleDOI
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells
Dora M. Kovacs,Hillary J. Fausett,Keith J. Page,Tae-Wan Kim,Robert D. Moir,David E. Merriam,Richard D. Hollister,Olivia G. Hallmark,Ronald Mancini,Kevin M. Felsenstein,Bradley T. Hyman,Rudolph E. Tanzi,Wilma Wasco +12 more
TL;DR: Using in situ hybridization, it is demonstrated that the expression patterns of PS1 and PS2 in the brain are extremely similar to each other and that messages for both are primarily detectable in neuronal populations.