L. Nee

TL;DR: A minimal cosegregating region containing the AD3 gene is defined, and at least 19 different transcripts encoded within this region corresponds to a novel gene whose product is predicted to contain multiple transmembrane domains and resembles an integral membrane protein.

TL;DR: Evidence is provided for a major early onset FAD locus on the long arm of chromosome 14 near the markers D14S43 and D 14S53 and it is suggested that the inheritance of FAD may be more complex than had initially been suspected.

TL;DR: The study supports the belief that, etiologically, DAT cannot be entirely accounted for by a single autosomal dominant gene and suggests that in certain genetic circumstances, disease expression may be delayed in females.

TL;DR: The similarity of pathologic findings in the different AD groups provides evidence for a final common pathophysiologic pathway in AD.

TL;DR: This novel Glu342Val mutation may cause FTDP‐17 by unprecedented mechanisms that alter splicing of E2, E3, and E10 to preferentially increase 4R tau without amino terminal inserts and promote aggregation of tau filaments into cytopathic inclusions.