L
Linda M. Brzustowicz
Researcher at Rutgers University
Publications - 112
Citations - 9347
Linda M. Brzustowicz is an academic researcher from Rutgers University. The author has contributed to research in topics: Autism & Schizophrenia (object-oriented programming). The author has an hindex of 42, co-authored 108 publications receiving 8973 citations. Previous affiliations of Linda M. Brzustowicz include Columbia University & Harvard University.
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Journal ArticleDOI
The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.
Rudolph E. Tanzi,Konstantin Petrukhin,Igor P. Chernov,Jean-Luc Pellequer,Wilma Wasco,B Ross,Donna M. Romano,Enrico Parano,Lorenzo Pavone,Linda M. Brzustowicz +9 more
TL;DR: The predicted functional properties of the pWD gene together with its strong homology to Mc1, genetic mapping data and identification of four independent disease–specific mutations, provide convincing evidence that pWD is the Wilson disease gene.
Journal ArticleDOI
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Cathryn M. Lewis,Douglas F. Levinson,Lesley H. Wise,Lynn E. DeLisi,Richard E. Straub,Iiris Hovatta,Nigel Williams,Sibylle G. Schwab,Ann E. Pulver,Stephen V. Faraone,Linda M. Brzustowicz,Linda M. Brzustowicz,Charles A. Kaufmann,David L. Garver,Hugh Gurling,Eva Lindholm,Hilary Coon,Hans W. Moises,William Byerley,Sarah H. Shaw,Andrea Mesén,Robin Sherrington,F. Anthony O'Neill,Dermot Walsh,Kenneth S. Kendler,Jesper Ekelund,Tiina Paunio,Jouko Lönnqvist,Leena Peltonen,Leena Peltonen,Michael Conlon O'Donovan,Michael John Owen,Dieter B. Wildenauer,Wolfgang Maier,Gerald Nestadt,Jean-Louis Blouin,Stylianos E. Antonarakis,Bryan J. Mowry,Jeremy M. Silverman,Raymond R. Crowe,C. Robert Cloninger,Ming T. Tsuang,Dolores Malaspina,Jill M. Harkavy-Friedman,Dragan M. Svrakic,Anne S. Bassett,Jennifer A. Holcomb,Gursharan Kalsi,Andrew McQuillin,Jon Brynjolfson,Thordur Sigmundsson,Hannes Petursson,Elena Jazin,Tómas Zoega,Tómas Helgason +54 more
TL;DR: The GSMA produced significant genomewide evidence for linkage on chromosome 2q and suggests that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations.
Journal ArticleDOI
Genetic mapping of chronic childhood-onset spinal muscular atrophy to chromosome 5q1 1.2–13.3
Linda M. Brzustowicz,Linda M. Brzustowicz,Thomas Lehner,Thomas Lehner,Lucio H. Castilla,Lucio H. Castilla,Penchaszadeh Gk,Penchaszadeh Gk,Kirk C. Wilhelmsen,Kirk C. Wilhelmsen,Rachael J. Daniels,Kay E. Davies,Mark Leppert,F. Ziter,D. Wood,Victor Dubowitz,Klaus Zerres,I. Hausmanowa-Petrusewicz,Jurg Ott,Jurg Ott,Theodore L. Munsat,T. C. Gilliam,T. C. Gilliam +22 more
TL;DR: Analysis of 13 clinically heterogeneous SMA families finds that 'chronic' childhood-onset SMA (including intermediate SMA or SMA type II, and KugelbergWelander or S MA type III) is genetically homogeneous, mapping to chromosomal region 5ql 1.3.
Journal ArticleDOI
Location of a Major Susceptibility Locus for Familial Schizophrenia on Chromosome 1q21-q22
Linda M. Brzustowicz,Kathleen A. Hodgkinson,Eva W.C. Chow,Eva W.C. Chow,William G. Honer,Anne S. Bassett,Anne S. Bassett +6 more
TL;DR: A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50.
Journal ArticleDOI
Mapping, Cloning and Genetic Characterization of the Region Containing the Wilson Disease Gene
Konstantin Petrukhin,Stuart G. Fischer,Mario Pirastu,Rudolph E. Tanzi,Igor P. Chernov,Marcella Devoto,Linda M. Brzustowicz,Eftihia Cayanis,Emilia Vitale,James J. Russo +9 more
TL;DR: This work developed yeast artificial chromosome and cosmid contigs, and microsatellite markers which span the WD gene region, and predicts that approximately half of all WD mutations will be rare in the American and Russian populations.