J
Janna A. van Diepen
Researcher at Radboud University Nijmegen
Publications - 46
Citations - 2385
Janna A. van Diepen is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Inflammation & Insulin resistance. The author has an hindex of 19, co-authored 38 publications receiving 1973 citations. Previous affiliations of Janna A. van Diepen include Leiden University Medical Center & Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
Rinke Stienstra,Leo A. B. Joosten,Tim B. Koenen,Berry van Tits,Janna A. van Diepen,Sjoerd A.A. van den Berg,Patrick C.N. Rensen,Peter J. Voshol,Giamilla Fantuzzi,Anneke Hijmans,Sander Kersten,Michael Müller,Wim B. van den Berg,Nico van Rooijen,Martin Wabitsch,Bart Jan Kullberg,Jos W. M. van der Meer,Thirumala D. Kanneganti,Cees J. Tack,Mihai G. Netea +19 more
TL;DR: The inflammasome is an important regulator of adipocyte function and insulin sensitivity, and caspase-1 inhibition may represent a novel therapeutic target in clinical conditions associated with obesity and insulin resistance.
Journal ArticleDOI
Interactions between inflammation and lipid metabolism: relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis.
Janna A. van Diepen,Jimmy F.P. Berbée,Jimmy F.P. Berbée,Louis M. Havekes,Patrick C.N. Rensen +4 more
TL;DR: The clinical trials that are currently conducted to evaluate the efficacy of anti-inflammatory agents in the treatment of cardiovascular diseases may additionally reveal potential (beneficial) effects of these therapeutics on lipid metabolism in the general population at risk for CVD.
Journal ArticleDOI
IL-37 protects against obesity-induced inflammation and insulin resistance
Dov B. Ballak,Janna A. van Diepen,Alexander R. Moschen,H.J. Jansen,Anneke Hijmans,Gert-Jan Groenhof,Floris Leenders,Philip Bufler,Mark V. Boekschoten,Michael Müller,Sander Kersten,Suzhao Li,Soohyun Kim,Hadar Eini,Eli C. Lewis,Leo A. B. Joosten,Herbert Tilg,Mihai G. Netea,Cees J. Tack,Charles A. Dinarello,Rinke Stienstra +20 more
TL;DR: It is shown that IL-1 family member IL-37, recently characterized as an anti-inflammatory cytokine, ameliorates obesity-induced inflammation and insulin resistance in both mice and humans and is suggested as a potential target for the treatment of Obesity-induced insulin resistance and type 2 diabetes.
Journal ArticleDOI
IL-1 family members in the pathogenesis and treatment of metabolic disease: Focus on adipose tissue inflammation and insulin resistance.
Dov B. Ballak,Dov B. Ballak,Dov B. Ballak,Rinke Stienstra,Cees J. Tack,Charles A. Dinarello,Janna A. van Diepen +6 more
TL;DR: Current knowledge and understanding of how the IL-1 family of cytokines affects the initiation and progression of obesity-induced insulin resistance have increased significantly are reviewed, with emphasis on the therapeutic potential of individual members of the interleukin-1family of cytokine for improving insulin sensitivity in patients with diabetes.
Journal ArticleDOI
Allosteric Regulation of Glycogen Synthase Controls Glycogen Synthesis in Muscle
Michale Bouskila,Roger W. Hunter,Adel F. M. Ibrahim,Lucie Delattre,Mark Peggie,Janna A. van Diepen,Peter J. Voshol,Jørgen Jensen,Jørgen Jensen,Kei Sakamoto +9 more
TL;DR: This study provides genetic evidence that allosteric activation of GS is the primary mechanism by which insulin promotes muscle glycogen accumulation in vivo and demonstrates that knockin mice expressing the G6P-insensitive mutant display an ∼80% reduced Muscle glycogen synthesis by insulin and markedly reduced glycogen levels.