S
Sjoerd A.A. van den Berg
Researcher at Leiden University Medical Center
Publications - 48
Citations - 3361
Sjoerd A.A. van den Berg is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Insulin resistance & Adipose tissue. The author has an hindex of 27, co-authored 48 publications receiving 3014 citations. Previous affiliations of Sjoerd A.A. van den Berg include Leiden University.
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Journal ArticleDOI
Inflammasome is a central player in the induction of obesity and insulin resistance
Rinke Stienstra,Janna A. van Diepen,Cees J. Tack,Hasan Zaki,Frank L. van de Veerdonk,Deshani Perera,Geoffrey Neale,Guido J. E. J. Hooiveld,Anneke Hijmans,Irene O.C.M. Vroegrijk,Sjoerd A.A. van den Berg,Johannes A. Romijn,Patrick C.N. Rensen,Leo A. B. Joosten,Mihai G. Netea,Thirumala-Devi Kanneganti +15 more
TL;DR: It is demonstrated that mice deficient in Nlrp3, apoptosis-associated speck-like protein, and caspase-1 were resistant to the development of high-fat diet-induced obesity, which correlated with protection from obesity-induced insulin resistance, and inhibition of the inflammasome is suggested as a potential therapeutic strategy.
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The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity
Rinke Stienstra,Leo A. B. Joosten,Tim B. Koenen,Berry van Tits,Janna A. van Diepen,Sjoerd A.A. van den Berg,Patrick C.N. Rensen,Peter J. Voshol,Giamilla Fantuzzi,Anneke Hijmans,Sander Kersten,Michael Müller,Wim B. van den Berg,Nico van Rooijen,Martin Wabitsch,Bart Jan Kullberg,Jos W. M. van der Meer,Thirumala D. Kanneganti,Cees J. Tack,Mihai G. Netea +19 more
TL;DR: The inflammasome is an important regulator of adipocyte function and insulin sensitivity, and caspase-1 inhibition may represent a novel therapeutic target in clinical conditions associated with obesity and insulin resistance.
Journal ArticleDOI
Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity
Claudia P. Coomans,Sjoerd A.A. van den Berg,Thijs Houben,Jan-Bert van Klinken,Rosa van den Berg,Amanda C. M. Pronk,Louis M. Havekes,Johannes A. Romijn,Ko Willems van Dijk,Nienke R. Biermasz,Johanna H. Meijer +10 more
TL;DR: A reduction in amplitude of the SCN is sufficient to induce a complete loss of circadian rhythms in energy metabolism and insulin sensitivity, as well as abolishment of normal circadian variation in insulin sensitivity in LL.
Journal ArticleDOI
The Suprachiasmatic Nucleus Controls Circadian Energy Metabolism and Hepatic Insulin Sensitivity
Claudia P. Coomans,Sjoerd A.A. van den Berg,Eliane A. Lucassen,Thijs Houben,Amanda C. M. Pronk,Rianne van der Spek,Andries Kalsbeek,Nienke R. Biermasz,Ko Willems van Dijk,Johannes A. Romijn,Johanna H. Meijer +10 more
TL;DR: The data show that SCN malfunctioning plays an important role in the disturbance of energy balance and suggest that an absence of central clock activity, in a genetically intact animal, may lead to the development of insulin resistance.
Journal ArticleDOI
Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice
Irene O.C.M. Vroegrijk,Janna A. van Diepen,Sjoerd A.A. van den Berg,Irene Westbroek,Hiskias G. Keizer,Luisa Gambelli,Raquel Hontecillas,Josep Bassaganya-Riera,Gerben Zondag,Johannes A. Romijn,Louis M. Havekes,Peter J. Voshol,Peter J. Voshol +12 more
TL;DR: It is concluded that dietary PSO ameliorates high-fat diet induced obesity and insulin resistance in mice, independent of changes in food intake or energy expenditure.