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Wolfram Gronwald
Researcher at University of Regensburg
Publications - 117
Citations - 3926
Wolfram Gronwald is an academic researcher from University of Regensburg. The author has contributed to research in topics: Internal medicine & Kidney disease. The author has an hindex of 30, co-authored 108 publications receiving 3432 citations. Previous affiliations of Wolfram Gronwald include Case Western Reserve University & University of Alberta.
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Journal ArticleDOI
Combined chemical shift changes and amino acid specific chemical shift mapping of protein–protein interactions
Frank Schumann,Hubert Riepl,Till Maurer,Wolfram Gronwald,Klaus-Peter Neidig,Hans Robert Kalbitzer +5 more
TL;DR: Combined chemical shifts can also be applied for a more reliable quantitative evaluation of titration data.
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State-of-the art data normalization methods improve NMR-based metabolomic analysis.
Stefanie M. Kohl,Matthias S. Klein,Jochen Hochrein,Peter J. Oefner,Rainer Spang,Wolfram Gronwald +5 more
TL;DR: Different data normalization methods were compared systematically employing two different datasets generated by means of nuclear magnetic resonance (NMR) spectroscopy, and preprocessing methods originally developed for DNA microarray analysis performed best in reducing bias, accurately detecting fold changes, and classifying samples.
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Advances in amino acid analysis
TL;DR: There is still room for further improvement, including expansion of the analyte spectrum, reduction of sample preparation and analysis time, automation, and synthesis of affordable isotope standards.
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Automated GC–MS analysis of free amino acids in biological fluids
TL;DR: A gas chromatography-mass spectrometry (GC-MS) method was developed for the quantitative analysis of free amino acids as their propyl chloroformate derivatives in biological fluids as mentioned in this paper.
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A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population
Peggy Sekula,Oemer Necmi Goek,Lydia Quaye,Clara Barrios,Andrew S. Levey,Werner Römisch-Margl,Cristina Menni,Idil Yet,Christian Gieger,Lesley A. Inker,Jerzy Adamski,Wolfram Gronwald,Thomas Illig,Katja Dettmer,Jan Krumsiek,Peter J. Oefner,Ana M. Valdes,Ana M. Valdes,Christa Meisinger,Josef Coresh,Tim D. Spector,Robert P. Mohney,Karsten Suhre,Gabi Kastenmüller,Anna Köttgen +24 more
TL;DR: A nontargeted metabolomics approach using gas and liquid chromatography coupled to mass spectrometry to quantify 493 small molecules in human serum provides a comprehensive list of kidney function-associated metabolites and highlights potential novel filtration markers that may help to improve the estimation of GFR.