W
Woo-Shin Shim
Researcher at University of Virginia
Publications - 4
Citations - 323
Woo-Shin Shim is an academic researcher from University of Virginia. The author has contributed to research in topics: Estrogen & Receptor. The author has an hindex of 4, co-authored 4 publications receiving 318 citations.
Papers
More filters
Journal ArticleDOI
Estradiol hypersensitivity and mitogen-activated protein kinase expression in long-term estrogen deprived human breast cancer cells in vivo.
Woo-Shin Shim,Mark R. Conaway,Shigeru Masamura,Wei Yue,Ji-Ping Wang,Rakesh Kumar,Richard J. Santen +6 more
TL;DR: It is demonstrated that hypersensitivity to E2 could occur under more complex in vivo conditions and that MAP kinase activation is enhanced under these circumstances.
Journal ArticleDOI
Adaptive hypersensitivity to estradiol: potential mechanism for secondary hormonal responses in breast cancer patients.
Richard J. Santen,Meei-Huey Jeng,Ji-ping Wang,R.X. Song,Shigeru Masamura,Robert A. McPherson,Steven J. Santner,Wei Yue,Woo-Shin Shim +8 more
TL;DR: Surprisingly, a series of experiments suggested that MAP kinase increased in hypersensitive cells as a result of estrogen activation via a non-genomic pathway and suggest that the cell membrane ER pathway may be responsible for upregulation ofMAP kinase and hypersensitivity in cells adapted to estradiol deprivation.
Journal ArticleDOI
Segregation of steroid receptor coactivator-1 from steroid receptors in mammary epithelium
TL;DR: It is suggested that SRC-1 is not necessary for ERalpha-mediated induction of PR in mammary epithelial cells and is also not sufficient for PR induction in stromal cells expressing both ERalpha and S RC-1.