W
Wood Mja.
Researcher at University of Oxford
Publications - 27
Citations - 3154
Wood Mja. is an academic researcher from University of Oxford. The author has contributed to research in topics: Spinal muscular atrophy & SMA*. The author has an hindex of 16, co-authored 27 publications receiving 2075 citations.
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Journal ArticleDOI
Advances in oligonucleotide drug delivery
TL;DR: An overview of oligonucleotide-based drug platforms is provided, focusing on key approaches — including chemical modification, bioconjugation and the use of nanocarriers — which aim to address the delivery challenge.
Journal ArticleDOI
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Lydia Alvarez-Erviti,Yiqi Seow,Anthony H.V. Schapira,Chris Gardiner,Ian L. Sargent,Wood Mja.,J M Cooper +6 more
TL;DR: This study demonstrates the importance of exosomes in both the release of alpha synuclein and its transmission between cells and suggests that factors associated with PD pathology accelerate this process.
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Antisense oligonucleotides: the next frontier for treatment of neurological disorders
Carlo Rinaldi,Wood Mja. +1 more
TL;DR: With the rapid development of improved next-generation ASOs toward clinical application, this technology now holds the potential to have a dramatic effect on the treatment of many neurological conditions in the near future.
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Microvesicles and exosomes: Opportunities for cell-derived membrane vesicles in drug delivery
S M van Dommelen,Pieter Vader,S Lakhal,Kooijmans Saa.,W. W. van Solinge,Wood Mja.,Raymond M. Schiffelers +6 more
TL;DR: Two approaches to exploit CMVs for delivery of exogenous therapeutic cargoes in vivo are currently considered and both are promising for the development of a potentially novel generation of drug carriers based on CMVs.
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The CRTC1-SIK1 pathway regulates entrainment of the circadian clock.
Aarti Jagannath,R Butler,R Butler,Godinho Sih.,Godinho Sih.,Yvonne Couch,Laurence A. Brown,Sridhar R. Vasudevan,Kevin C. Flanagan,Daniel C. Anthony,Grant C. Churchill,Wood Mja.,G Steiner,Martin Ebeling,M Hossbach,Joseph G. Wettstein,Giles E. Duffield,Silvia Gatti,Mark W. Hankins,Russell G. Foster,Stuart N. Peirson +20 more
TL;DR: Analysis of the light-regulated transcriptome of the SCN has identified a key role for salt inducible kinase 1 (SIK1) and CREB-regulated transcription coactivator 1 (CRTC1) in clock re-setting and provides a potential target for the regulation of circadian rhythms.