D
Dorien De Vlieger
Researcher at Ghent University
Publications - 14
Citations - 1170
Dorien De Vlieger is an academic researcher from Ghent University. The author has contributed to research in topics: Influenza A virus & Nucleoprotein. The author has an hindex of 9, co-authored 14 publications receiving 773 citations.
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Journal ArticleDOI
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
Daniel Wrapp,Dorien De Vlieger,Kizzmekia S. Corbett,Gretel M. Torres,Nianshuang Wang,Wander Van Breedam,Kenny Roose,Loes van Schie,Markus Hoffmann,Stefan Pöhlmann,Barney S. Graham,Nico Callewaert,Bert Schepens,Xavier Saelens,Jason S. McLellan +14 more
TL;DR: The isolation of single-domain antibodies (VHHs) from a llama immunized with prefusion-stabilized coronavirus spikes provide a molecular basis for the neutralization of pathogenic betacoronaviruses by VHHs and suggest that these molecules may serve as useful therapeutics during coronav virus outbreaks.
Journal ArticleDOI
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.
Robbert Boudewijns,Robbert Boudewijns,Hendrik Jan Thibaut,Hendrik Jan Thibaut,Suzanne J.F. Kaptein,Suzanne J.F. Kaptein,Rong Li,Valentijn Vergote,Laura Seldeslachts,Johan Van Weyenbergh,Carolien De Keyzer,Carolien De Keyzer,Lindsey Bervoets,Lindsey Bervoets,Sapna Sharma,Sapna Sharma,Laurens Liesenborghs,Laurens Liesenborghs,Ji Ma,Ji Ma,Sander Jansen,Sander Jansen,Dominique Van Looveren,Dominique Van Looveren,Thomas Vercruysse,Thomas Vercruysse,Xinyu Wang,Xinyu Wang,Dirk Jochmans,Dirk Jochmans,Erik Martens,Kenny Roose,Dorien De Vlieger,Bert Schepens,Tina Van Buyten,Tina Van Buyten,Sofie Jacobs,Sofie Jacobs,Yanan Liu,Joan Martí-Carreras,Bert Vanmechelen,Tony Wawina-Bokalanga,Leen Delang,Leen Delang,Joana Rocha-Pereira,Joana Rocha-Pereira,Lotte Coelmont,Lotte Coelmont,Winston Chiu,Winston Chiu,Pieter Leyssen,Pieter Leyssen,Elisabeth Heylen,Elisabeth Heylen,Dominique Schols,Lanjiao Wang,Lanjiao Wang,Lila Close,Jelle Matthijnssens,Marc Van Ranst,Veerle Compernolle,Georg Schramm,Koen Van Laere,Xavier Saelens,Nico Callewaert,Ghislain Opdenakker,Piet Maes,Birgit Weynand,Christopher Cawthorne,Greetje Vande Velde,Zhongde Wang,Johan Neyts,Johan Neyts,Kai Dallmeier,Kai Dallmeier +74 more
TL;DR: The results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.
Journal ArticleDOI
Erratum: Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies (Cell (2020) 181(5) (1004–1015.e15), (S0092867420304943), (10.1016/j.cell.2020.04.031))
Daniel Wrapp,Dorien De Vlieger,Kizzmekia S. Corbett,Gretel M. Torres,Nianshuang Wang,Wander Van Breedam,Kenny Roose,Loes van Schie,Markus Hoffmann,Markus Hoffmann,Stefan Pöhlmann,Stefan Pöhlmann,Barney S. Graham,Nico Callewaert,Bert Schepens,Xavier Saelens,Jason S. McLellan +16 more
Journal ArticleDOI
Single-Domain Antibodies and Their Formatting to Combat Viral Infections
TL;DR: This review focuses on VHH formats that have been developed to combat viruses including influenza viruses, human immunodeficiency virus-1 (HIV-1), and human respiratory syncytial virus (RSV).
Posted ContentDOI
Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies
Daniel Wrapp,Dorien De Vlieger,Kizzmekia S. Corbett,Gretel M. Torres,Wander Van Breedam,Kenny Roose,Loes van Schie,Vib-Cmb Covid Response Team,Markus Hoffmann,Stefan Pöhlmann,Barney S. Graham,Nico Callewaert,Bert Schepens,Xavier Saelens,Jason S. McLellan +14 more
TL;DR: The isolation and characterization of single-domain antibodies (VHHs) from a llama immunized with prefusion-stabilized coronavirus spikes are described and a molecular basis for the neutralization of pathogenic betacoronaviruses by VHHs is provided and it is suggested that these molecules may serve as useful therapeutics during coronav virus outbreaks.