Xian Chen

TL;DR: The renal-clearable and host-guest recognition-based NIR-II biolabels developed in this study provide a promising platform to monitor the physiological behaviors of biomolecules in living organisms.

TL;DR: A simple and ultrasensitive electrochemical DNA biosensor using long-range self-assembled DNA nanostructures as carriers for signal amplification, which can achieve an impressive detection limit of 5 aM human immunodeficiency virus (HIV) DNA even in complex biological samples.

TL;DR: An ultrasensitive electrochemical biosensor for detection of cancer-associated circulating miRNAs based on DNA concatamers amplification that showed a high sensitivity for target miRNA-21 in a concentration range from 100 aM to 100 pM with a detection limit of100 aM is developed.

TL;DR: A simple, ultrasensitive and selective electrochemical DNA biosensor based on DNA concatamers is described, which can detect as low as 100 aM target DNA even in complex samples.

TL;DR: A facile and universal strategy for phase transfer and surface biofunctionalization of hydrophobic nanomaterials using aptamer-pendant DNA tetrahedron nanostructures (Apt-tet), which may become a new paradigm in phase-transfer-agent design and further expand biomedical applications of hydrophic nanoparticles.