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Xiao Shu
Researcher at Children's Hospital Oakland Research Institute
Publications - 5
Citations - 605
Xiao Shu is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: Lipid droplet & Apolipoprotein B. The author has an hindex of 5, co-authored 5 publications receiving 549 citations.
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Journal ArticleDOI
Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 Plays a Critical Role in the Lipolytic Processing of Chylomicrons
Anne P. Beigneux,Brandon S.J. Davies,Peter Gin,Michael M. Weinstein,Emily Farber,Xin Qiao,Franklin Peale,Stuart Bunting,Rosemary L. Walzem,Jinny S. Wong,William S. Blaner,Zhi-Ming Ding,Kristan Melford,Nuttaporn Wongsiriroj,Xiao Shu,Fred de Sauvage,Robert O. Ryan,Loren G. Fong,André Bensadoun,Stephen G. Young +19 more
TL;DR: It is shown that glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) plays a critical role in the lipolytic processing of chylomicrons in capillaries.
Journal ArticleDOI
Apolipoprotein A-V associates with intrahepatic lipid droplets and influences triglyceride accumulation.
TL;DR: Intrahepatic apoA-V was associated with LD isolated from livers of wild type and APOA5 Tg mice suggesting that apo-V influences intra heparin-releasable TG levels.
Journal ArticleDOI
Apolipoprotein A-V association with intracellular lipid droplets
TL;DR: The data suggest that apoA-V has a unique association with cellular lipids and, therefore, may be involved in the storage or mobilization of intracellular lipids.
Journal ArticleDOI
Intravenous Injection of Apolipoprotein A-V Reconstituted High-Density Lipoprotein Decreases Hypertriglyceridemia in apoav−/− Mice and Requires Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein–Binding Protein 1
Xiao Shu,Lisa Nelbach,Michael M. Weinstein,Braydon L. Burgess,Jennifer A. Beckstead,Stephen G. Young,Robert O. Ryan,Trudy M. Forte +7 more
TL;DR: Its intravenous administration may have therapeutic benefit in human subjects with severe HTG, especially in cases involving apoA-V variants associated with HTG.
Journal ArticleDOI
Intracellular lipid droplet targeting by apolipoprotein A-V requires the carboxyl-terminal segment
TL;DR: Data suggest that the C terminus of apoA-V is essential for lipid droplet association in transfected hepatoma cells and lipoprotein association in conditioned medium while the signal peptide is required for extracellular trafficking of this protein.