K
Kristan Melford
Researcher at Cornell University
Publications - 16
Citations - 1036
Kristan Melford is an academic researcher from Cornell University. The author has contributed to research in topics: Lipoprotein lipase & GPIHBP1. The author has an hindex of 12, co-authored 16 publications receiving 969 citations. Previous affiliations of Kristan Melford include Children's Hospital Oakland Research Institute.
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Journal ArticleDOI
Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 Plays a Critical Role in the Lipolytic Processing of Chylomicrons
Anne P. Beigneux,Brandon S.J. Davies,Peter Gin,Michael M. Weinstein,Emily Farber,Xin Qiao,Franklin Peale,Stuart Bunting,Rosemary L. Walzem,Jinny S. Wong,William S. Blaner,Zhi-Ming Ding,Kristan Melford,Nuttaporn Wongsiriroj,Xiao Shu,Fred de Sauvage,Robert O. Ryan,Loren G. Fong,André Bensadoun,Stephen G. Young +19 more
TL;DR: It is shown that glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1) plays a critical role in the lipolytic processing of chylomicrons in capillaries.
Journal ArticleDOI
Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase
Anne P. Beigneux,Remco Franssen,André Bensadoun,Peter Gin,Kristan Melford,Jorge Peter,Rosemary L. Walzem,Michael M. Weinstein,Brandon S.J. Davies,Jan Albert Kuivenhoven,John J.P. Kastelein,Loren G. Fong,Geesje M. Dallinga-Thie,Stephen G. Young +13 more
TL;DR: A homozygous missense mutation in GPIHBP1 (Q115P) was identified in a 33-year-old male with lifelong chylomicronemia, strongly suggesting that it caused the patient’s chylomaticronemia.
Journal Article
Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice (vol 283, pg 34511, 2008)
Michael M. Weinstein,Liya Yin,Anne P. Beigneux,Brandon S.J. Davies,Peter Gin,Kristine D. Estrada,Kristan Melford,Joseph R. Bishop,Jeffrey D. Esko,Geesje M. Dallinga-Thie,Loren G. Fong,André Bensadoun,Stephen G. Young +12 more
Journal ArticleDOI
Abnormal Patterns of Lipoprotein Lipase Release into the Plasma in GPIHBP1-deficient Mice
Michael M. Weinstein,Liya Yin,Anne P. Beigneux,Brandon S.J. Davies,Peter Gin,Kristine D. Estrada,Kristan Melford,Joseph R. Bishop,Jeffrey D. Esko,Geesje M. Dallinga-Thie,Loren G. Fong,André Bensadoun,Stephen G. Young +12 more
TL;DR: The differences in LPL release after intravenous heparin and Intralipid strongly suggest that GPIHBP1 represents an important binding site for LPL in vivo.
Journal ArticleDOI
Heparin decreases the degradation rate of lipoprotein lipase in adipocytes.
TL;DR: The increase in lipoprotein lipase protein secretion, observed upon addition of heparin to cultured adipocytes, is due to a decreased degradation rate with no change in synthetic rate, and newly synthesized lipop protein lipase in cultured adipocyte is secreted constitutively and there is no evidence that it is stored in an intracellular pool.