X
Xiaoguang Lei
Researcher at Peking University
Publications - 169
Citations - 5877
Xiaoguang Lei is an academic researcher from Peking University. The author has contributed to research in topics: Total synthesis & Chemistry. The author has an hindex of 30, co-authored 140 publications receiving 4465 citations. Previous affiliations of Xiaoguang Lei include Peking Union Medical College & Tianjin University.
Papers
More filters
Journal ArticleDOI
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
Liming Sun,Huayi Wang,Zhigao Wang,Sudan He,She Chen,Daohong Liao,Lai Wang,Jiacong Yan,Weilong Liu,Xiaoguang Lei,Xiaodong Wang +10 more
TL;DR: The identification of a small molecule called necrosulfonamide that specifically blocks necrosis downstream of RIP3 activation is reported, which implicate MLKL as a key mediator of necrosis signaling downstream of the kinase RIP3.
Journal ArticleDOI
Crystal structure of the FTO protein reveals basis for its substrate specificity
Zhifu Han,Tianhui Niu,Junbiao Chang,Xiaoguang Lei,Mingyan Zhao,Qiang Wang,Wei Cheng,Jinjing Wang,Yi Feng,Jijie Chai +9 more
TL;DR: The crystal structure of FTO in complex with the mononucleotide 3-meT provides a structural basis for understanding FTO substrate-specificity, and serves as a foundation for the rational design of Fto inhibitors.
Journal ArticleDOI
Late-Stage Diversification of Natural Products.
TL;DR: This outlook will outline selected examples of novel methodologies for site-selective transformations of reactive functional groups and inert C–H bonds that enable late-stage diversification of complex natural products.
Journal ArticleDOI
Small-molecule activation of the TRAIL receptor DR5 in human cancer cells
Gelin Wang,Xiaoming Wang,Hong Yu,Shuguang Wei,Noelle S. Williams,Daniel L. Holmes,Randal Halfmann,Jacinth Naidoo,Lai Wang,Lin Li,She Chen,Patrick G. Harran,Xiaoguang Lei,Xiaodong Wang +13 more
TL;DR: This study identified potential lead compounds for the development of small-molecule TRAIL mimics targeting DR5 for cancer therapy and identified a more potent analog called bioymifi, which can act as a single agent to induce DR5 clustering and aggregation, leading to apoptosis.
Journal ArticleDOI
Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states
Dan Tan,Qiang Li,Mei-Jun Zhang,Chao Liu,Chengying Ma,Pan Zhang,Yue-He Ding,Sheng-Bo Fan,Li Tao,Bing Yang,Xiangke Li,Shoucai Ma,Jun-Jie Liu,Boya Feng,Xiaohui Liu,Hong-Wei Wang,Si-Min He,Ning Gao,Keqiong Ye,Meng-Qiu Dong,Xiaoguang Lei +20 more
TL;DR: A lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away from biotin after enrichment, and a spacer arm that can be labeled with stable isotopes for quantitation is developed.