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Xiaohua Liu
Researcher at Sichuan University
Publications - 363
Citations - 12383
Xiaohua Liu is an academic researcher from Sichuan University. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 54, co-authored 319 publications receiving 9818 citations.
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Journal ArticleDOI
Chiral Lewis acid-bonded picolinaldehyde enables enantiodivergent carbonyl catalysis in the Mannich/condensation reaction of glycine ester
Xia Zhong,Ziwei Zhong,Zhikun Wu,Zhen Ye,Yuxiang Feng,Shunxi Dong,Xiaohua Liu,Qian Peng,Xiaoming Feng +8 more
TL;DR: A new strategy of asymmetric carbonyl catalysis via a chiral Lewis acid-bonded aldehyde has been developed for the direct Mannich/condensation cascade reaction of glycine ester with aromatic aldimines, providing a series of trisubstituted imidazolidines in moderate to good yields with high diastereo- and enantioselectivities.
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Multisubstituted pyrazole synthesis via [3 + 2] cycloaddition/rearrangement/NH insertion cascade reaction of α-diazoesters and ynones
TL;DR: In this paper, the cascade reactions of alkyl α-diazoesters and ynones using Al(OTf)3 as the catalyst are described, and a series of 4substituted pyrazoles are obtained via [3 + + 2] cycloaddition, 1,5-ester shift, 1 3-H shift, and N H insertion process.
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Asymmetric Synthesis of α,β-Epoxy-γ-lactams through Tandem Darzens/Hemiaminalization Reaction.
TL;DR: A catalytic asymmetric tandem Darzens/hemiaminalization reaction of glyoxals with α-bromo-β-esteramides or α-flammable α,β-epoxy-γ-lactams was accomplished in moderate to good yields with excellent diastereo- and enantioselectivities.
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N,N’‐Dioxide–Lanthanum(III)‐Catalyzed Asymmetric Cyclopropanation of 2‐Cyano‐3‐arylacrylates with 2‐Bromomalonates
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Catalytic enantioselective ene-type reactions of vinylogous hydrazone: construction of α-methylene-γ-butyrolactone derivatives.
TL;DR: The catalytic asymmetric ene-type reactions of vinylogous hydrazone were accomplished by using chiral N,N'-dioxide-metal salt complexes as catalysts, providing a convenient way to synthesize bioactive chiral α-methylene-γ-butyrolactone derivatives.