Xiaohua Liu

TL;DR: The catalytic enantioselective [2+2] cycloaddition between quinones and fulvenes was achieved, for the first time, by the use of a chiral copper(ii) complex catalyst with good yields and excellent regio- and stereoselectivities.

TL;DR: A highly enantioselective ring-opening desymmetrization of meso-aziridines with isocyanides was achieved in the presence of a chiral N,N'-dioxide/Mg(OTf)2 complex, enabling a collective synthesis of various chiral vicinal amino-oxazoles, spiroindolines, β-amino amides, and tetrazole derivative in moderate to high yields with excellent enantilectivities.

TL;DR: Highly enantioselective C2 alkylation and inverse-electron-demand [3 + 2]-cycloaddition of 3-methylindoles with 2,2′-diester aziridine with chemodivergent synthesis were accomplished.

TL;DR: A rare boat-like transition-state model was proposed to elucidate the origin of high chirality transfer during the oxy-Cope rearrangement and moderate to good yields and excellent ee values were obtained.

TL;DR: A direct asymmetric vinylogous aldol reaction of nonactivated natural α-angelica lactone to isatins has been developed with a N,N'-dioxide-Sc(OTf)3 complex as catalyst, and a possible transition state was proposed to explain the origin of the asymmetric induction.