Xiaohua Liu

TL;DR: A nickel(ii) catalyzed enantioselective thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles was realized with modified chiral N,N'-dioxide ligands, affording a variety of C3-substituted indole derivatives in high yields with excellent enantiOSElectivities under mild reaction conditions.

TL;DR: An asymmetric Meerwein-Ponndorf-Verley (MPV) reduction of glyoxylates was for the first time accomplished via an N,N'-dioxide/Y(OTf)3 complex with aluminium alkoxide and molecular sieves as crucial additives.

TL;DR: In this paper, the authors describe the development of a kinetic resolution and asymmetric rearrangement of racemic propargyl vinyl ethers, which enabled chiral allene products along with the enantiomerically enriched substrate in good yields with excellent diastereo and enantioselectivity.

TL;DR: An enantioselective tandem Friedel–Crafts alkylation–hemiketalization between electron-rich phenols and α,β-unsaturated ketoesters gave a direct approach to chiral 2,3-disubstituted chromans in the presence of a chiral N,N′-dioxide/Sc(OTf)3 complex.

TL;DR: An asymmetric tandem cycloisomerization and intermolecular [5+2] cycloaddition reaction of 2-ethynylphenyl-substituted nitrones with methyleneindolinones was realized and a possible transition state model was proposed.