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Xiaohua Liu
Researcher at Sichuan University
Publications - 363
Citations - 12383
Xiaohua Liu is an academic researcher from Sichuan University. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 54, co-authored 319 publications receiving 9818 citations.
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Journal ArticleDOI
Catalytic Asymmetric Intramolecular Homologation of Ketones with α-Diazoesters: Synthesis of Cyclic α-Aryl/Alkyl β-Ketoesters
TL;DR: Under mild conditions, a variety of aryl- and alkyl-substituted ketone groups reacted with α-diazoester groups smoothly through an intramolecular addition/rearrangement process, producing the β-ketoesters in high yield and enantiomeric excess.
Journal ArticleDOI
Highly enantioselective synthesis of 1,3-bis(hydroxymethyl)-2-oxindoles from unprotected oxindoles and formalin using a chiral NdIII complex
Ke Shen,Xiaohua Liu,Wentao Wang,Gang Wang,Weidi Cao,Wei Li,Xiaolei Hu,Lili Lin,Xiaoming Feng +8 more
TL;DR: Highly enantioselective synthesis of 1,3-bis(hydroxymethyl)-2-oxindoles was established through chiral NdIII-N,N′-dioxide in up to 93% yield and >99% ee under mild conditions.
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Stereodivergent synthesis of vicinal quaternary-quaternary stereocenters and bioactive hyperolactones.
TL;DR: A nickel-catalyzed enantioselective dearomatization Claisen rearrangement leading to vicinal all-carbon stereocentres is reported and applied to the stereodivergent synthesis of bioactive hyperolactones.
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Nickel-Catalyzed Conjugate Addition of Silyl Ketene Imines to In Situ Generated Indol-2-ones: Highly Enantioselective Construction of Vicinal All-Carbon Quaternary Stereocenters
TL;DR: The first enantioselective conjugate addition of silyl ketene imines to in situ generated indol-2-ones was performed in the presence of a chiral N,N'-dioxide/NiII catalyst, providing efficient access to chiral β-alkyl nitriles bearing congested vicinal all-carbon quaternary stereocenters.
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Enantioselective Synthesis of 3,4-Dihydropyran Derivatives via Organocatalytic Michael Reaction of α,β-Unsaturated Enones
TL;DR: A simple chiral diamine catalyst was successfully applied in the asymmetric Michael reaction between cyclic dimedone and α,β-unsaturated ketones and the desired adducts were obtained in high yields with excellent enantioselectivities.