Reinforcement learning, one of the most active research areas in artificial intelligence, is a computational approach to learning whereby an agent tries to maximize the total amount of reward it receives when interacting with a complex, uncertain environment. In Reinforcement Learning, Richard Sutton and Andrew Barto provide a clear and simple account of the key ideas and algorithms of reinforcement learning. Their discussion ranges from the history of the field's intellectual foundations to the most recent developments and applications. The only necessary mathematical background is familiarity with elementary concepts of probability. The book is divided into three parts. Part I defines the reinforcement learning problem in terms of Markov decision processes. Part II provides basic solution methods: dynamic programming, Monte Carlo methods, and temporal-difference learning. Part III presents a unified view of the solution methods and incorporates artificial neural networks, eligibility traces, and planning; the two final chapters present case studies and consider the future of reinforcement learning.

/pdf/reinforcement-learning-an-introduction-rzxgej9p17.pdf

Reinforcement Learning: An Introduction

Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe a powerful analytical method called Gene Set Enrichment Analysis (GSEA) for interpreting gene expression data. The method derives its power by focusing on gene sets, that is, groups of genes that share common biological function, chromosomal location, or regulation. We demonstrate how GSEA yields insights into several cancer-related data sets, including leukemia and lung cancer. Notably, where single-gene analysis finds little similarity between two independent studies of patient survival in lung cancer, GSEA reveals many biological pathways in common. The GSEA method is embodied in a freely available software package, together with an initial database of 1,325 biologically defined gene sets.

/pdf/gene-set-enrichment-analysis-a-knowledge-based-approach-for-mbpti6qljw.pdf

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

http://bartellab.wi.mit.edu/publication_reprints/Bartel_Cell09.pdf

MicroRNAs: Target Recognition and Regulatory Functions

Estimating3D hand poses from RGB images is essentialto a wide range of potential applications, but is challengingowing to substantial ambiguity in the inference of depth in-formation from RGB images. State-of-the-art estimators ad-dress this problem by regularizing3D hand pose estimationmodels during training to enforce the consistency betweenthe predicted3D poses and the ground-truth depth maps.However, these estimators rely on both RGB images and thepaired depth maps during training. In this study, we proposea conditional generative adversarial network (GAN) model,called Depth-image Guided GAN (DGGAN), to generate re-alistic depth maps conditioned on the input RGB image, anduse the synthesized depth maps to regularize the3D handpose estimation model, therefore eliminating the need forground-truth depth maps. Experimental results on multiplebenchmark datasets show that the synthesized depth mapsproduced by DGGAN are quite effective in regularizing thepose estimation model, yielding new state-of-the-art resultsin estimation accuracy, notably reducing the mean3D end-point errors (EPE) by4.7%,16.5%, and6.8%on the RHD,STB and MHP datasets, respectively.

DGGAN: Depth-image Guided Generative Adversarial Networks for Disentangling RGB and Depth Images in 3D Hand Pose Estimation

We aimed to analyze the incidence rates of new‐onset diabetes, hypertriglyceridemia, hypercholesterolemia, liver injury, and renal injury during antiretroviral therapy (ART) among people living with HIV (PLWH) and determine the associated risk factors.

Longitudinal analysis of new‐onset non‐AIDS‐defining diseases among people living with HIV: A real‐world observational study

We consider the problem of covariance matrix estimation in the presence of latent variables. Under suitable conditions, it is possible to learn the marginal covariance matrix of the observed variables via a tractable convex program, where the concentration matrix of the observed variables is decomposed into a sparse matrix (representing the graphical structure of the observed variables) and a low rank matrix (representing the marginalization effect of latent variables). We present an efficient first-order method based on split Bregman to solve the convex problem. The algorithm is guaranteed to converge under mild conditions. We show that our algorithm is significantly faster than the state-of-the-art algorithm on both artificial and real-world data. Applying the algorithm to a gene expression data involving thousands of genes, we show that most of the correlation between observed variables can be explained by only a few dozen latent factors. AMS 2000 subject classifications: Applied statistics 97K80; Learning and adaptive systems 68T05; Convex programming 90C25.

Efficient Latent Variable Graphical Model Selection via Split Bregman Method

64 Systematic identification of human mitochondrial disease genes through integrative genomics

In this paper, we propose a new architecture named Rotation-invariant Mixed Graphical Model Network (R-MGMN) to solve the problem of 2D hand pose estimation from a monocular RGB image. By integrating a rotation net, the R-MGMN is invariant to rotations of the hand in the image. It also has a pool of graphical models, from which a combination of graphical models could be selected, conditioning on the input image. Belief propagation is performed on each graphical model separately, generating a set of marginal distributions, which are taken as the confidence maps of hand keypoint positions. Final confidence maps are obtained by aggregating these confidence maps together. We evaluate the R-MGMN on two public hand pose datasets. Experiment results show our model outperforms the state-of-the-art algorithm which is widely used in 2D hand pose estimation by a noticeable margin.

/pdf/rotation-invariant-mixed-graphical-model-network-for-2d-hand-46tf3cas9t.pdf

Xiaohui Xie

Papers

DGGAN: Depth-image Guided Generative Adversarial Networks for Disentangling RGB and Depth Images in 3D Hand Pose Estimation

Longitudinal analysis of new‐onset non‐AIDS‐defining diseases among people living with HIV: A real‐world observational study

Efficient Latent Variable Graphical Model Selection via Split Bregman Method

64 Systematic identification of human mitochondrial disease genes through integrative genomics

Rotation-invariant Mixed Graphical Model Network for 2D Hand Pose Estimation