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Xiaoliang Zhuo
Researcher at University at Albany, SUNY
Publications - 6
Citations - 251
Xiaoliang Zhuo is an academic researcher from University at Albany, SUNY. The author has contributed to research in topics: Genetically modified mouse & Olfactory mucosa. The author has an hindex of 6, co-authored 6 publications receiving 235 citations. Previous affiliations of Xiaoliang Zhuo include New York State Department of Health.
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Journal Article
Biotransformation of Coumarin by Rodent and Human Cytochromes P-450: Metabolic Basis of Tissue-Selective Toxicity in Olfactory Mucosa of Rats and Mice
Xiaoliang Zhuo,Jun Gu,Qing Yu Zhang,David C. Spink,Laurence S. Kaminsky,Xinxin Ding,Xinxin Ding +6 more
TL;DR: Aim of this study was to explore the role of target tissue biotransformation in OM-selective toxicity and the metabolic basis of the species differences in coumarin toxicity, andKinetic analysis and immunoinhibition studies indicated that the OM-specific CYP2G1 plays the major role in metabolic activation of coumarIn.
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Regulation of cytochrome P450 gene expression in the olfactory mucosa
TL;DR: This mini-review is to provide a summary of current knowledge of the various modes of regulation of CYPs expressed in the OM, an update on mechanistic studies on tissue-selective CYP expression, and a review of the literature on xenobiotic inducibility of OM CYPs.
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Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.
Lin Wu,Jun Gu,Yan Weng,Kerri Kluetzman,Pam Swiatek,Melissa Behr,Qing Yu Zhang,Xiaoliang Zhuo,Qiang Xie,Xinxin Ding,Xinxin Ding +10 more
TL;DR: The Cprlox strain will be valuable for conditional Cpr gene deletion and subsequent determination of the impact of CPR loss on the metabolism of endogenous and xenobiotic compounds, as well as on postnatal development and other biological functions.
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Targeted Disruption of the Olfactory Mucosa-Specific Cyp2g1 Gene: Impact on Acetaminophen Toxicity in the Lateral Nasal Gland, and Tissue-Selective Effects on Cyp2a5 Expression
Xiaoliang Zhuo,Jun Gu,Melissa Behr,Pam Swiatek,Pam Swiatek,Huadong Cui,Qing Yu Zhang,Yingqiu Xie,Doris N. Collins,Xinxin Ding,Xinxin Ding +10 more
TL;DR: It is hypothesized that OM CYP2G1 (through a paracrine pathway) or LNG CyP2A5 may indirectly influence resistance of the LNG to chemical toxicity, possibly by regulating gene expression in the L NG through steroid hormones or other endogenous P450 substrates and their metabolites.
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Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6.
Qing Yu Zhang,Jun Gu,Ting Su,Huadong Cui,Xiuling Zhang,Jaime D'Agostino,Xiaoliang Zhuo,Weizhu Yang,Pamela J. Swiatek,Xinxin Ding +9 more
TL;DR: Systemic clearance of coumarin was significantly higher in the transgenic mice than in B6 controls, consistent with the predicted role of CYP2A6 as the major coumarIn hydroxylase in human liver.