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Yuan Sun
Researcher at Chinese Academy of Sciences
Publications - 31
Citations - 1754
Yuan Sun is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Coronavirus & Viral replication. The author has an hindex of 13, co-authored 31 publications receiving 1209 citations. Previous affiliations of Yuan Sun include South China Agricultural University.
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Journal ArticleDOI
Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.
Peng Zhou,Hang Fan,Tian Lan,Xing-Lou Yang,Weifeng Shi,Wei Zhang,Yan Zhu,Ya-Wei Zhang,Qingmei Xie,Shailendra Mani,Xiao-Shuang Zheng,Bei Li,Jinman Li,Hua Guo,Guangqian Pei,Xiaoping An,Jun-Wei Chen,Ling Zhou,Kai-jie Mai,Zixian Wu,Di Li,Danielle E. Anderson,Libiao Zhang,Shi-Yue Li,Zhiqiang Mi,Tongtong He,Feng Cong,Pengju Guo,Ren Huang,Yun Luo,Xiang-Ling Liu,Jing Chen,Yong Huang,Qiang Sun,Xianglilan Zhang,Yuan-Yuan Wang,Shaozhen Xing,Yan-Shan Chen,Yuan Sun,Juan Li,Peter Daszak,Lin-Fa Wang,Zhengli Shi,Yigang Tong,Jingyun Ma +44 more
TL;DR: Analysis of viral samples from deceased piglets shows that a bat coronav virus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease.
Journal ArticleDOI
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Zhenming Jin,Zhenming Jin,Yao Zhao,Yuan Sun,Bing Zhang,Haofeng Wang,Haofeng Wang,Yan Wu,Yan Zhu,Chen Zhu,Tianyu Hu,Xiaoyu Du,Xiaoyu Du,Yinkai Duan,Jing Yu,Xiaobao Yang,Xiuna Yang,Kailin Yang,Xiang Liu,Luke W. Guddat,Gengfu Xiao,Leike Zhang,Haitao Yang,Zihe Rao,Zihe Rao,Zihe Rao +25 more
TL;DR: The X-ray crystal structure of SARS-CoV-2 with inhibitor carmofur reveals the mechanism of action of this compound and opens the way to develop more potent drugs.
Journal ArticleDOI
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension
Lei Ke Zhang,Yuan Sun,Haolong Zeng,Qingxing Wang,Xiaming Jiang,Wei juan Shang,Yan Wu,Shufen Li,Yu Lan Zhang,Zhao Nian Hao,Hongbo Chen,Runming Jin,Wei Liu,Hao Li,Ke Peng,Gengfu Xiao +15 more
TL;DR: In this article, the authors reported that calcium channel blockers (CCBs), a type of antihypertensive drug that is widely used in clinics, inhibited the post-entry replication events of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro.
Journal ArticleDOI
Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Rui Xiong,Leike Zhang,Shiliang Li,Yuan Sun,Minyi Ding,Yong Wang,Yongliang Zhao,Yan Wu,Weijuan Shang,Xiaming Jiang,Jiwei Shan,Zihao Shen,Yi Tong,Liuxin Xu,Yu Chen,Yingle Liu,Gang Zou,Dimitri Lavillete,Zhenjiang Zhao,Rui Wang,Lili Zhu,Gengfu Xiao,Ke Lan,Honglin Li,Ke Xu,Ke Xu +25 more
TL;DR: This work demonstrates that both S312/S416 and old drugs with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide, no matter such viruses are mutated or not.
Posted ContentDOI
Calcium channel blocker amlodipine besylate is associated with reduced case fatality rate of COVID-19 patients with hypertension
Leike Zhang,Yuan Sun,Hao-Long Zeng,Yudong Peng,Xiaming Jiang,Weijuan Shang,Yan Wu,Shufen Li,Yulan Zhang,Liu Yang,Hongbo Chen,Runming Jin,Wei Liu,Hao Li,Ke Peng,Gengfu Xiao +15 more
TL;DR: It is reported that calcium channel blockers (CCBs), a type of anti-hypertension drugs that are widely used in the clinics, can significantly inhibit the post-entry replication events of SARS-CoV-2 in vitro.