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Xiaoyu Xiang
Researcher at University of Louisville
Publications - 23
Citations - 5060
Xiaoyu Xiang is an academic researcher from University of Louisville. The author has contributed to research in topics: Microvesicles & Exosome. The author has an hindex of 17, co-authored 21 publications receiving 3957 citations. Previous affiliations of Xiaoyu Xiang include University of Alabama at Birmingham & University of Alabama.
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Journal ArticleDOI
A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes
Dongmei Sun,Xiaoying Zhuang,Xiaoying Zhuang,Xiaoyu Xiang,Xiaoyu Xiang,Yuelong Liu,Shuangyin Zhang,Cunren Liu,Stephen Barnes,William E. Grizzle,Donald R. Miller,Huang-Ge Zhang +11 more
TL;DR: It is reported that exosomes can deliver anti-inflammatory agents, such as curcumin, to activated myeloid cells in vivo, and the therapeutic relevance of this technique is validated in a lipopolysaccharide (LPS)-induced septic shock mouse model.
Journal ArticleDOI
Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain
Xiaoying Zhuang,Xiaoyu Xiang,William E. Grizzle,Dongmei Sun,Shuangqin Zhang,Robert C. Axtell,Songwen Ju,Jiangyao Mu,Lifeng Zhang,Lawrence Steinman,Donald R. Miller,Huang-Ge Zhang,Huang-Ge Zhang +12 more
TL;DR: Exosomes used to encapsulate curcumin or a signal transducer and activator of transcription 3 (Stat3) inhibitor were delivered noninvasively to microglia cells via an intranasal route and demonstrated that this strategy may provide a noninvasive and novel therapeutic approach for treating brain inflammatory-related diseases.
Journal ArticleDOI
Induction of myeloid-derived suppressor cells by tumor exosomes
Xiaoyu Xiang,Anton Poliakov,Cunren Liu,Yuelong Liu,Zhongbin Deng,Jianhua Wang,Ziqiang Cheng,Spandan V. Shah,Gui-Jun Wang,Liming Zhang,William E. Grizzle,James A. Mobley,Huang-Ge Zhang,Huang-Ge Zhang +13 more
TL;DR: These findings lend themselves to developing specific targetable therapeutic strategies to reduce or eliminate MDSC‐induced immunosuppression and hence enhance host antitumor immunotherapy efficacy.
Journal ArticleDOI
Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis.
Songwen Ju,Jingyao Mu,Terje Dokland,Xiaoying Zhuang,Qilong Wang,Hong Jiang,Xiaoyu Xiang,Zhongbin Deng,Baomei Wang,Lifeng Zhang,Mary R. Roth,Ruth Welti,James A. Mobley,Yan Jun,Donald R. Miller,Huang-Ge Zhang,Huang-Ge Zhang +16 more
TL;DR: It is shown that the cells targeted by grape exosome-like nanoparticles (GELNs) are intestinal stem cells whose responses underlie the GELN-mediated intestinal tissue remodeling and protection against dextran sulfate sodium (DSS)-induced colitis.
Journal ArticleDOI
Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance
Zhongbin Deng,Anton Poliakov,Robert W. Hardy,Ronald H. Clements,Cunren Liu,Yuelong Liu,Jianhua Wang,Xiaoyu Xiang,Shuangqin Zhang,Xiaoying Zhuang,Spandan V. Shah,Dongmei Sun,Sue Michalek,William E. Grizzle,Timothy W Garvey,James A. Mobley,Huang-Ge Zhang +16 more
TL;DR: ELVs released by adipose tissue can act as a mode of communication between adipose tissues and macrophages and insulin resistance requires the TLR4/TRIF pathway.