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Shuangyin Zhang
Researcher at University of Alabama at Birmingham
Publications - 6
Citations - 1650
Shuangyin Zhang is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Microvesicles & Exosome. The author has an hindex of 5, co-authored 6 publications receiving 1331 citations. Previous affiliations of Shuangyin Zhang include University of Alabama.
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Journal ArticleDOI
A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes
Dongmei Sun,Xiaoying Zhuang,Xiaoying Zhuang,Xiaoyu Xiang,Xiaoyu Xiang,Yuelong Liu,Shuangyin Zhang,Cunren Liu,Stephen Barnes,William E. Grizzle,Donald R. Miller,Huang-Ge Zhang +11 more
TL;DR: It is reported that exosomes can deliver anti-inflammatory agents, such as curcumin, to activated myeloid cells in vivo, and the therapeutic relevance of this technique is validated in a lipopolysaccharide (LPS)-induced septic shock mouse model.
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Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells
Yuelong Liu,Xiaoyu Xiang,Xiaoyu Xiang,Xiaoying Zhuang,Xiaoying Zhuang,Shuangyin Zhang,Cunren Liu,Ziqiang Cheng,Sue Michalek,William E. Grizzle,Huang-Ge Zhang,Huang-Ge Zhang,Huang-Ge Zhang +12 more
TL;DR: In this paper, the authors observed that mice pretreated with tumor exosomes had a significant acceleration of tumor metastasis in the lung, which correlated significantly with an increase in recruitment of more Myeloid-derived suppressor cells (MDSCs) in the lungs of C57BL/6j (B6) mice.
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Immature myeloid cells induced by a high fat diet contribute to liver inflammation
Zhongbin Deng,Yuelong Liu,Cunren Liu,Xiaoyu Xiang,Jianhua Wang,Ziqiang Cheng,Spandan V. Shah,Shuangyin Zhang,Liming Zhang,Xiaoying Zhuang,Sue Michalek,William E. Grizzle,Huang-Ge Zhang,Huang-Ge Zhang +13 more
TL;DR: Consumption of a high‐fat diet by B6 mice triggers an accumulation of immature myeloid cells in the liver that release proinflammatory cytokines and induce NKT cell apoptosis and may contribute to obesity‐related liver disease.
Journal ArticleDOI
miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT
Xiaoyu Xiang,Xiaoying Zhuang,Songwen Ju,Shuangyin Zhang,Hong Jiang,Jingyao Mu,Lifeng Zhang,Donald R. Miller,William E. Grizzle,Huang-Ge Zhang,Huang-Ge Zhang +10 more
TL;DR: It is reported that stable expression of miR-155 in 4T1 breast tumor cells reduces significantly the aggressiveness of tumor cell dissemination as a result of preventing epithelial-to-mesenchymal transition (EMT) of tumor cells in vivo.
Journal ArticleDOI
Plant homologue constitutive photomorphogenesis 9 (COP9) signalosome subunit CSN5 regulates innate immune responses in macrophages.
Zhongbin Deng,Ruggero Pardi,William G. Cheadle,Xiaoyu Xiang,Shuangyin Zhang,Spandan V. Shah,William E. Grizzle,Donald R. Miller,John D. Mountz,Huang-Ge Zhang,Huang-Ge Zhang +10 more
TL;DR: It is shown that the COP9 signalosome subunit 5 (CSN5) is required for activation of proinflammatory kinases p38 and Erk and for down-regulation of the expression of genes regulated by nuclear factor E2-related factor 2.