Z
Zhongbin Deng
Researcher at University of Louisville
Publications - 48
Citations - 5038
Zhongbin Deng is an academic researcher from University of Louisville. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 24, co-authored 38 publications receiving 3370 citations. Previous affiliations of Zhongbin Deng include University of Alabama at Birmingham & University of Alabama.
Papers
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Journal ArticleDOI
Induction of myeloid-derived suppressor cells by tumor exosomes
Xiaoyu Xiang,Anton Poliakov,Cunren Liu,Yuelong Liu,Zhongbin Deng,Jianhua Wang,Ziqiang Cheng,Spandan V. Shah,Gui-Jun Wang,Liming Zhang,William E. Grizzle,James A. Mobley,Huang-Ge Zhang,Huang-Ge Zhang +13 more
TL;DR: These findings lend themselves to developing specific targetable therapeutic strategies to reduce or eliminate MDSC‐induced immunosuppression and hence enhance host antitumor immunotherapy efficacy.
Journal ArticleDOI
Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis.
Songwen Ju,Jingyao Mu,Terje Dokland,Xiaoying Zhuang,Qilong Wang,Hong Jiang,Xiaoyu Xiang,Zhongbin Deng,Baomei Wang,Lifeng Zhang,Mary R. Roth,Ruth Welti,James A. Mobley,Yan Jun,Donald R. Miller,Huang-Ge Zhang,Huang-Ge Zhang +16 more
TL;DR: It is shown that the cells targeted by grape exosome-like nanoparticles (GELNs) are intestinal stem cells whose responses underlie the GELN-mediated intestinal tissue remodeling and protection against dextran sulfate sodium (DSS)-induced colitis.
Journal ArticleDOI
Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota
Yun Teng,Yi Ren,Mohammed Sayed,Xin Hu,Chao Lei,Anup Kumar,Elizabeth Hutchins,Jingyao Mu,Zhongbin Deng,Chao Luo,Kumaran Sundaram,Mukesh K. Sriwastva,Lifeng Zhang,Michael Hsieh,Rebecca Reiman,Bodduluri Haribabu,Jun Yan,Venkatakrishna R. Jala,Donald M. Miller,Kendall Van Keuren-Jensen,Michael L. Merchant,Craig J. McClain,Craig J. McClain,Juw Won Park,Nejat K. Egilmez,Huang-Ge Zhang,Huang-Ge Zhang +26 more
TL;DR: It is demonstrated that plant-derived exosome-like nanoparticles (ELNs) are taken up by the gut microbiota and contain RNAs that alter microbiome composition and host physiology and reveal how plant products and their effects on the microbiome may be used to target specific host processes to alleviate disease.
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Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance
Zhongbin Deng,Anton Poliakov,Robert W. Hardy,Ronald H. Clements,Cunren Liu,Yuelong Liu,Jianhua Wang,Xiaoyu Xiang,Shuangqin Zhang,Xiaoying Zhuang,Spandan V. Shah,Dongmei Sun,Sue Michalek,William E. Grizzle,Timothy W Garvey,James A. Mobley,Huang-Ge Zhang +16 more
TL;DR: ELVs released by adipose tissue can act as a mode of communication between adipose tissues and macrophages and insulin resistance requires the TLR4/TRIF pathway.
Journal ArticleDOI
Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles
Jingyao Mu,Xiaoying Zhuang,Qilong Wang,Hong Jiang,Zhongbin Deng,Baomei Wang,Lifeng Zhang,Sham S. Kakar,Yan Jun,Donald R. Miller,Huang-Ge Zhang,Huang-Ge Zhang +11 more
TL;DR: A role for EPDEN-mediated interspecies communication is suggested by inducing expression of genes for anti-inflammation cytokines, antioxidation, and activation of Wnt signaling, which are crucial for maintaining intestinal homeostasis.