L
Liming Zhang
Researcher at University of Alabama at Birmingham
Publications - 11
Citations - 2000
Liming Zhang is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Microvesicles & T cell. The author has an hindex of 9, co-authored 11 publications receiving 1784 citations. Previous affiliations of Liming Zhang include University of Alabama.
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Journal ArticleDOI
Induction of myeloid-derived suppressor cells by tumor exosomes
Xiaoyu Xiang,Anton Poliakov,Cunren Liu,Yuelong Liu,Zhongbin Deng,Jianhua Wang,Ziqiang Cheng,Spandan V. Shah,Gui-Jun Wang,Liming Zhang,William E. Grizzle,James A. Mobley,Huang-Ge Zhang,Huang-Ge Zhang +13 more
TL;DR: These findings lend themselves to developing specific targetable therapeutic strategies to reduce or eliminate MDSC‐induced immunosuppression and hence enhance host antitumor immunotherapy efficacy.
Journal ArticleDOI
Murine Mammary Carcinoma Exosomes Promote Tumor Growth by Suppression of NK Cell Function
Cunren Liu,Shaohua Yu,Kurt R. Zinn,Jianhua Wang,Liming Zhang,Yujiang Jia,John C. Kappes,Stephen Barnes,Robert P. Kimberly,William E. Grizzle,Huang-Ge Zhang,Huang-Ge Zhang +11 more
TL;DR: It is proposed that tumor exosomes contribute to the growth of tumors by blocking IL-2-mediated activation of NK cells and their cytotoxic response to tumor cells.
Journal ArticleDOI
Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells
Shaohua Yu,Cunren Liu,Kaihong Su,Jianhua Wang,Yuelong Liu,Liming Zhang,Chuanyu Li,Yingzi Cong,Robert P. Kimberly,William E. Grizzle,Carla I. Falkson,Huang-Ge Zhang,Huang-Ge Zhang +12 more
TL;DR: It is demonstrated that TS/A exosomes block the differentiation of murine myeloid precursor cells into dendritic cells (DC) in vitro, and data suggest that tumor exosome-mediated induction of IL-6 plays a role in blocking BM DC differentiation.
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A Membrane Form of TNF-α Presented by Exosomes Delays T Cell Activation-Induced Cell Death
Huang-Ge Zhang,Huang-Ge Zhang,Cunren Liu,Kaihong Su,Shaohua Yu,Liming Zhang,Shuangqin Zhang,Jianhua Wang,Xu Cao,William E. Grizzle,Robert P. Kimberly +10 more
TL;DR: It is shown that the exosomes produced by synovial fibroblasts obtained from individuals with rheumatoid arthritis (RASF) contain a membrane bound form of TNF-α, which is effectively taken up by anti-CD3-activated T cells, activated AKT and NF-κB and rendered these activated T cells resistant to apoptosis.
Journal ArticleDOI
Thymus Exosomes-Like Particles Induce Regulatory T Cells
Gui-Jun Wang,Yuelong Liu,Yuelong Liu,Aijian Qin,Spandan V. Shah,Zhongbin Deng,Xiaoyu Xiang,Ziqiang Cheng,Cunren Liu,Jianhua Wang,Liming Zhang,William E. Grizzle,Huang-Ge Zhang,Huang-Ge Zhang +13 more
TL;DR: It is shown that neutralization of TGF-β in ELPs partially reverses thymic ELP-mediated induction of CD4+Foxp3+ T cells in the lung and liver and might be required for the generation of Tregs in the peripheral tissues.