Xinjun Zhu

TL;DR: Autophagy is suppressed in brain tissues of forebrain-specific conditional TSC1 and phosphatase and tensin homlog knock-out mice and impaired autophagy contributes to epileptogenesis, which may be of interest as a potential therapeutic target for epilepsy treatment and/or prevention.

TL;DR: It is demonstrated that elevated mTOR signaling in mouse microglia leads to phenotypic changes, including an amoeboid-like morphology, increased proliferation, and robust phagocytosis activity, but without a significant induction of pro-inflammatory cytokines.

TL;DR: In this paper, SLC9A3 missense, splicing and truncation mutations, including an instance of uniparental disomy, and whole-gene deletion were identified in nine patients from eight families with CSD.

TL;DR: It is demonstrated that leucine regulates insulin secretion by modulating adrenergic α2 receptors through the mTOR pathway, which represents a double-hit to pancreatic islets that synergistically disturbs glucose homeostasis.

TL;DR: It is confirmed that two previously created Cx3cr1-Cre lines remain as invaluable tools for studying microglia and it should be compulsory to thoroughly examine reporter lines for spontaneous leakiness when labeling cells to study CNS function and diseases.