A
Aleixo M. Muise
Researcher at University of Toronto
Publications - 131
Citations - 7118
Aleixo M. Muise is an academic researcher from University of Toronto. The author has contributed to research in topics: Inflammatory bowel disease & Medicine. The author has an hindex of 42, co-authored 108 publications receiving 5663 citations. Previous affiliations of Aleixo M. Muise include Ludwig Maximilian University of Munich & Dalhousie University.
Papers
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Journal ArticleDOI
The diagnostic approach to monogenic very early onset inflammatory bowel disease.
Holm H. Uhlig,Tobias Schwerd,Sibylle Koletzko,Neil Shah,Neil Shah,Jochen Kammermeier,Abdul Elkadri,Jodie Ouahed,Jodie Ouahed,David C. Wilson,David C. Wilson,Simon Travis,Dan Turner,Christoph Klein,Scott B. Snapper,Scott B. Snapper,Aleixo M. Muise +16 more
TL;DR: Key intestinal, extraintestinal, and laboratory features of 50 genetic variants associated with IBD-like intestinal inflammation are described and approaches for identifying patients likely to have these disorders are provided.
Journal ArticleDOI
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Marcin Imielinski,Robert N. Baldassano,Anne M. Griffiths,Richard K Russell,Vito Annese,Marla Dubinsky,Subra Kugathasan,Jonathan P. Bradfield,Thomas D. Walters,Patrick M. A. Sleiman,Cecilia E. Kim,Aleixo M. Muise,Kai Wang,Joseph T. Glessner,Shehzad Ahmed Saeed,Haitao Zhang,Edward C. Frackelton,Cuiping Hou,James H. Flory,George Otieno,Rosetta M. Chiavacci,Robert W. Grundmeier,Massimo Castro,Anna Latiano,Bruno Dallapiccola,Joanne M. Stempak,Debra J. Abrams,Kent D. Taylor,Dermot P.B. McGovern,Melvin B. Heyman,George D. Ferry,Barbara S. Kirschner,Jessica T. Lee,Jonah Essers,Richard J. Grand,Michael C. Stephens,Arie Levine,David A. Piccoli,Johan Van Limbergen,Salvatore Cucchiara,Dimitri S. Monos,Stephen L. Guthery,Lee A. Denson,David C. Wilson,Struan F.A. Grant,Mark J. Daly,Mark S. Silverberg,Jack Satsangi,Hakon Hakonarson +48 more
TL;DR: The results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America are reported, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD.
Journal ArticleDOI
Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function
Dror S. Shouval,Dror S. Shouval,Amlan Biswas,Amlan Biswas,Jeremy A. Goettel,Jeremy A. Goettel,Katelyn McCann,Evan Conaway,Naresh Singh Redhu,Naresh Singh Redhu,Ivan D. Mascanfroni,Ziad Al Adham,Sydney Lavoie,Mouna Ibourk,Deanna D. Nguyen,Janneke N. Samsom,Johanna C. Escher,Raz Somech,Raz Somech,Batia Weiss,Batia Weiss,Rita Beier,Laurie S. Conklin,Christen L. Ebens,Fernanda Stephanie Santos,Alexandre Rodrigues Ferreira,Mark Sherlock,Atul K. Bhan,Werner Müller,J. Rodrigo Mora,Francisco J. Quintana,Christoph Klein,Aleixo M. Muise,Bruce H. Horwitz,Bruce H. Horwitz,Scott B. Snapper +35 more
TL;DR: It is shown that IL-10 sensing by innate immune cells, independent of its effects on T cells, was critical for regulating mucosal immune homeostasis in mice and humans and in patients with very early onset inflammatory bowel disease.
Book ChapterDOI
Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans.
Dror S. Shouval,Jodie Ouahed,Amlan Biswas,Jeremy A. Goettel,Bruce H. Horwitz,Christoph Klein,Aleixo M. Muise,Scott B. Snapper +7 more
TL;DR: Recent findings on how IL10- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine gastrointestinal tract are reviewed, with implications of their role in the prevention of inflammatory bowel disease (IBD).
Journal ArticleDOI
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis
Christopher J. Moran,Christopher J. Moran,Thomas D. Walters,Conghui Guo,Subra Kugathasan,Christoph Klein,Dan Turner,Victorien M. Wolters,Robert H. J. Bandsma,Marialena Mouzaki,Mary Zachos,Jacob C. Langer,Ernest Cutz,Susanne M. Benseler,Chaim M. Roifman,Mark S. Silverberg,Anne M. Griffiths,Scott B. Snapper,Aleixo M. Muise +18 more
TL;DR: This study identified the first splice site mutation in IL10RA resulting in infantile-onset IBD and expands the phenotype ofIL10RA polymorphisms to include both severe arthritis and VEO-UC.