Martha Ritsema

TL;DR: As shown using clonal assays, the mouse HSC population undergoes quantitative as well as qualitative changes with age, including lineage differentiation, HSC pool size, marrow-homing efficiency, and self-renewal.

TL;DR: It is shown that in the haematopoietic system this process is governed by polycomb chromobox (Cbx) proteins, and the presence of distinct Cbx proteins confers target selectivity to PRC1 and provides a molecular balance between self-renewal and differentiation of HSCs.

TL;DR: Cellular barcoding combined with multiplex high-throughput sequencing is used to provide a quantitative and sensitive analysis of clonal behavior of hundreds of young and old HSCs, demonstrating that the pool of old H SCs is composed of multiple small clones, whereas the young HSC pool is dominated by fewer, but larger, clones.

TL;DR: Surprisingly, a major role of this conserved pathway in maintaining DNA and cellular integrity is revealed, explaining how impaired CoA synthesis during CNS development can elicit a neurodegenerative phenotype.

TL;DR: It is shown that a single member of the miR-cluster, namely miR/let-7e/125a, is responsible for the majority of the observed hematopoietic phenotypes upon transplantation and candidate target genes through whichmiR-125a may modulate HSPC fate are identified.