S
Sandra Olthof
Researcher at University Medical Center Groningen
Publications - 18
Citations - 1181
Sandra Olthof is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Progenitor cell & Stem cell. The author has an hindex of 11, co-authored 18 publications receiving 1063 citations.
Papers
More filters
Journal ArticleDOI
Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells
TL;DR: As shown using clonal assays, the mouse HSC population undergoes quantitative as well as qualitative changes with age, including lineage differentiation, HSC pool size, marrow-homing efficiency, and self-renewal.
Journal ArticleDOI
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
Karin Klauke,Visnja Radulovic,Mathilde J.C. Broekhuis,Ellen Weersing,Erik Zwart,Sandra Olthof,Martha Ritsema,Sophia W.M. Bruggeman,Xudong Wu,Kristian Helin,Leonid Bystrykh,Gerald de Haan +11 more
TL;DR: It is shown that in the haematopoietic system this process is governed by polycomb chromobox (Cbx) proteins, and the presence of distinct Cbx proteins confers target selectivity to PRC1 and provides a molecular balance between self-renewal and differentiation of HSCs.
Journal ArticleDOI
Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis
TL;DR: It is demonstrated that BMI1 expression is required for maintenance and self-renewal of normal and leukemic stem and progenitor cells, and that expression of BMI1 protects cells against oxidative stress.
Journal ArticleDOI
Genetic screen identifies microRNA cluster 99b/let-7e/125a as a regulator of primitive hematopoietic cells
Alice Gerrits,Marta A. Walasek,Sandra Olthof,Ellen Weersing,Martha Ritsema,Erik Zwart,Ronald van Os,Leonid Bystrykh,Gerald de Haan +8 more
TL;DR: It is shown that a single member of the miR-cluster, namely miR/let-7e/125a, is responsible for the majority of the observed hematopoietic phenotypes upon transplantation and candidate target genes through whichmiR-125a may modulate HSPC fate are identified.
Journal ArticleDOI
BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells.
Aleksandra Rizo,Sarah J. Horton,Sandra Olthof,Bert Dontje,Albertina Ausema,Ronald van Os,Vincent van den Boom,Edo Vellenga,Gerald de Haan,Jan Jacob Schuringa +9 more
TL;DR: It is shown that BMI1 collaborates with BCR-ABL in inducing a fatal leukemia in nonobese diabetic/severe combined immunodeficiency mice transplanted with transduced human CD34(+) cells within 4-5 months.