Showing papers by "Xudong Xu published in 2013"
TL;DR: This paper mainly focuses on screening and characterization of phenols (including flavonoids), alkaloids, terpenoids, steroids, coumarins, lignans, and miscellaneous compounds in respective herbs and biological samples, as well as traditional Chinese medicine prescriptions using tandem mass spectrometer.
155 citations
TL;DR: It is suggested that administration of the PTF-b enriched in CQAs moderates hyperlipidemia and improves the liver lipid profile.
Abstract: Hyperlipidemia is considered to be one of the greatest risk factors contributing to the prevalence and severity of cardiovascular diseases. In this work, we investigated the anti-hyperlipidemic effect and potential mechanism of action of the Pandanus tectorius fruit extract in hamsters fed a high fat-diet (HFD). The n-butanol fraction of the P. tectorius fruit ethanol extract (PTF-b) was rich in caffeoylquinic acids (CQAs). Administration of PTF-b for 4 weeks effectively decreased retroperitoneal fat and the serum levels of total cholesterol (TC), triglycerides (TG) and low density lipoprotein–cholesterol (LDL-c) and hepatic TC and TG. The lipid signals (fatty acids, and cholesterol) in the liver as determined by nuclear magnetic resonance (NMR) were correspondingly reduced. Realtime quantitative PCR showed that the mRNA levels of PPARα and PPARα-regulated genes such as ACO, CPT1, LPL and HSL were largely enhanced by PTF-b. The transcription of LDLR, CYP7A1, and PPARγ was also upregulated. Treatment with PTF-b significantly stimulated the activation of AMP-activated protein kinase (AMPK) as well as the activity of serum and hepatic lipoprotein lipase (LPL). Together, these results suggest that administration of the PTF-b enriched in CQAs moderates hyperlipidemia and improves the liver lipid profile. These effects may be caused, at least in part, by increasing the expression of PPARα and its downstream genes and by upregulation of LPL and AMPK activities.
92 citations
TL;DR: New structures, synthesis, and bioactivity of Daphniphyllum alkaloids reported in recent years are presented and several inspired organic syntheses were completed.
Abstract: The unique polycyclic fused ring systems of Daphniphyllum alkaloids, along with their extensive bioactivities, make this family of alkaloids especially attractive targets for total synthesis and biogenetic studies. Successive discoveries of new alkaloids with unprecedented skeletons have made a great contribution to structural diversities of alkaloids elaborated by plants of the genus Daphniphyllum. By the end of 2008, more than 200 alkaloids belonging to 14 different skeletal types have been isolated from different parts of plants of thirteen Daphniphyllum species. These alkaloids show cytotoxic, antioxidant, vasorelaxant, and antiplatelet activating factor effects. The plausible biosynthetic pathways for Daphniphyllum alkaloids have been proposed and biomimetic total syntheses of some alkaloids completed. To provide an update of the previous reviews published in 2009, new structures, synthesis, and bioactivity of Daphniphyllum alkaloids reported in recent years are presented in this article. In the meantime, an additional 54 novel alkaloids have been isolated and identified. Among them, some possess unprecedented frameworks. Several inspired organic syntheses were completed.
80 citations
TL;DR: Eight new cassane-type diterpenes, caesalpins A-H (1-8), were isolated from the ethyl acetate extract of Caesalpinia minax, and compounds 2 and 4 exhibited selective cytotoxic activities against MCF-7 and AGS cells.
Abstract: Eight new cassane-type diterpenes, caesalpins A-H (1-8), were isolated from the ethyl acetate extract of Caesalpinia minax. Compound 1 displayed significant antiproliferative activity against HepG-2 (IC50 4.7 μM) and MCF-7 (IC50 2.1 μM) cells, and compounds 2 and 4 exhibited selective cytotoxic activities against MCF-7 (IC50 7.9 μM) and AGS (IC50 6.5 μM) cells.
41 citations
TL;DR: The fragmentation pathways proposed in this paper were helpful for the identification of different types of flavone C-glycosides when no reference standards were available.
32 citations
TL;DR: Two new triterpenoid saponins were isolated from the roots of Platycodon grandiflorum and showed remarkable cytotoxic activities against HepG-2 and A549 cancer cell lines with IC(50) values ranging from 4.9 to 9.4 µM, but they displayed weak cytot toxic activities against DU145 cancer cell line with IC('50' values greater than 10 µM.
Abstract: Two new triterpenoid saponins, named platycodon A (3-O-β-D-glucopyranosyl-16-O-β-D-glucopyranosyl-2β,3β,16β,21β-tetrahydroxyolean-12-en-28-oic acid) and platycodon B (3-O-β-D-glucopyranosyl-16-O-β-D-xylopyranosyl-2β,3β,16β,21β-tetrahydroxyolean-12-en-28-oic acid) were isolated from the roots of Platycodon grandiflorum. The structures of these compounds were elucidated by means of various spectroscopic analyses. Compounds 1 and 2 were tested in HepG-2, A549 and DU145 human cancer cell lines and showed remarkable cytotoxic activities against HepG-2 and A549 cancer cell lines with IC(50) values ranging from 4.9 to 9.4 µM, but they displayed weak cytotoxic activities against DU145 cancer cell line with IC(50) values greater than 10 µM.
20 citations
TL;DR: A new eudesmanolide sesquiterpene, atractylenolide IV, together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae).
16 citations
TL;DR: In this paper, five phenylpropanoids including one new compound balanophonin A (1), one new natural compound BALANophonin B (2) were isolated from the seeds of Lithocarpus pachylepis for the first time.
14 citations
TL;DR: Four novel diterpenes possessing rare five-membered peroxide ring, aphanaperoxides E-H (1-4), were isolated from stem bark of Aphanamixis polystachya and the cytotoxicities of the isolated compounds against a panel of human cancer cell lines were evaluated.
14 citations
TL;DR: Three new triterpene saponins were isolated from the Tabellae Clinopodii and showed moderate cytotoxic activities with IC₅₀ values between 4.1 and 19.7 μM.
12 citations
TL;DR: Two new cassane-type diterpenes were isolated from Caesalpinia minax Hance and showed mild cytotoxicity activities against colon carcinoma and breast cancer cell lines.
Patent•
18 Sep 2013
TL;DR: In this article, the Pandanus tectorius extract is extracted by water and/or alcohol, and then condensing and drying the extract to obtain the medicinal plant extract provided by the invention.
Abstract: The invention relate to a preparation method of a medicinal plant extract being capable of reducing blood fat and an application thereof in pharmacy and health food. The extract is prepared by using a medicinal plant-Pandanus tectorius in south of the Five Ridges as a raw material, extracting and separating. The preparation method comprises extracting the Pandanus tectorius by water and/or alcohol, and then condensing and drying the extract to obtain the medicinal plant extract provided by the invention. The extract is dissolved in water, degreased, and extracted by an organic solvent to obtain an extraction part; or passes through macroporous adsorption resin, and then elute by water, methanol, ethanol, acetone or 60-90 % ethanol or aqueous acetone; the extract liquor or the eluent is collected, recovered under reduced pressure, condensed into extract, and then dried to obtain effective parts of the medicinal plant extract. A plurality of pharmacodynamics experiments verify that the medicinal plant extract is capable of reducing the blood fat, can be used for preparing drugs or health products of reducing the blood fat, and thus is used for treating hyperlipidemia, obesity and other diseases.
TL;DR: Platycodon A (Ia) and B (Ib) showed remarkable cytotoxic activities against HepG-2 and A549 cancer cell lines.
Abstract: isolation and structure determination of platycodon A (Ia) and B (Ib), which show remarkable cytotoxic activities against HepG-2 and A549 cancer cell lines