Journal ArticleDOI
Recent developments in qualitative and quantitative analysis of phytochemical constituents and their metabolites using liquid chromatography-mass spectrometry.
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This paper mainly focuses on screening and characterization of phenols (including flavonoids), alkaloids, terpenoids, steroids, coumarins, lignans, and miscellaneous compounds in respective herbs and biological samples, as well as traditional Chinese medicine prescriptions using tandem mass spectrometer.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2013-01-18. It has received 155 citations till now. The article focuses on the topics: Chemical fingerprinting & Liquid chromatography–mass spectrometry.read more
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Current approaches and challenges for the metabolite profiling of complex natural extracts
TL;DR: A survey of the techniques that are used for generic and comprehensive profiling of secondary metabolites in natural extracts is provided and the structural information that can be generated through these techniques or in combination is compared in relation to the identification of metabolites in complex mixtures.
Journal ArticleDOI
Grape Pomace as a Sustainable Source of Bioactive Compounds: Extraction, Characterization, and Biotechnological Applications of Phenolics
TL;DR: This review summarizes the most recent developments in the extraction of polyphenols from GPs and the possible applications of GP extracts in diverse biotechnological fields are discussed.
Journal ArticleDOI
Isolation and characterization of bioactive compounds from plant resources: the role of analysis in the ethnopharmacological approach.
TL;DR: The aim of this review is to address natural-products chemists to the choice of the best methodologies, which include the combination of extraction/sample preparation tools and analytical techniques, for isolating and characterizing bioactive secondary metabolites from plants, as potential lead compounds in the drug discovery process.
Санкт-Петербургский государственный университет культуры и искусств
Abstract: The main characteristics of aqueous dispersions of nanoparticles are considered. One of the results of the work is the synthesis of calcium zirconate nanoparticles. The particles were obtained by the solution combustion method and analyzed by X-ray diffraction and X-ray fluorescence methods. The next step is to preparation of aqueous dispersion based on the synthesized nanoparticles, conducts studies on their stability, and carried out experiments to study the process of dispersion boiling. As a result, a conclusion has been made about a promising method of fixing nanoparticles on the heating surface. The obtained results showed that the heat exchange efficiency at the flat vertical heater is depended on exposure in the bubble boiling regime. The choice of nanoparticles and their concentration also have a significant influence at the discovered effect.
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Novel applications of mass spectrometry-based metabolomics in herbal medicines and its active ingredients: Current evidence.
TL;DR: The value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, and to enhance their biomedical value in biomedicine is highlighted.
References
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Journal ArticleDOI
The Orbitrap: a new mass spectrometer
TL;DR: The Orbitrap as mentioned in this paper is a mass analyzer based on an electrospray ionization source (ESI) with an outer barrel-like electrode, coaxial with the inner spindlelike electrode and mass/charge values measured from the frequency of harmonic ion oscillations along the axis of the electric field, undergone by the orbitally trapped ions.
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Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents)
TL;DR: The trend in the domestication, production and biotechnological studies and genetic improvement of medicinal plants will offer great advantages, since it will be possible to obtain uniform and high quality raw materials which are fundamental to the efficacy and safety of herbal drugs.
Journal ArticleDOI
Extraction, separation, and detection methods for phenolic acids and flavonoids
TL;DR: This review provides an updated and extensive overview of methods and their applications in natural product matrices and samples of biological origin and critically appraises recent developments and trends.
Journal ArticleDOI
Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses
TL;DR: The combination of polymeric mixed-mode SPE, the appropriate mobile phase pH and UPLC technology provides significant advantages for reducing matrix effects resulting from plasma matrix components and in improving the ruggedness and sensitivity of bioanalytical methods.
Journal ArticleDOI
Measurement of food flavonoids by high-performance liquid chromatography: A review.
Howard M. Merken,Gary R. Beecher +1 more
TL;DR: The flavonoids are plant polyphenols found frequently in fruits, vegetables, and grains and known for their hydrogen-donating antioxidant activity as well as their ability to complex divalent transition metal cations.
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