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Xuefeng Fang
Researcher at Zhejiang University
Publications - 5
Citations - 408
Xuefeng Fang is an academic researcher from Zhejiang University. The author has contributed to research in topics: Gene expression profiling & Transcription factor. The author has an hindex of 5, co-authored 5 publications receiving 375 citations. Previous affiliations of Xuefeng Fang include University of Washington.
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Journal ArticleDOI
The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis
Xuefeng Fang,Jae-Geun Yoon,Lisha Li,Wei Yu,Jiaofang Shao,Dasong Hua,Shu-Mei Zheng,Leroy Hood,David R. Goodlett,Gregory Foltz,Biaoyang Lin,Biaoyang Lin +11 more
TL;DR: It is shown that knockdown of the SOX2 gene in LN229 GBM cells reduces cell proliferation and colony formation, and thatSOX2 down regulates BEX1 and BEX2, two genes with tumor suppressor activity in GBM, potentially creating a bistable system in G BM cells.
Journal ArticleDOI
Integrated Expression Profiling and ChIP-seq Analyses of the Growth Inhibition Response Program of the Androgen Receptor
Biaoyang Lin,Jun Wang,Xu Hong,Xiaowei Yan,Daehee Hwang,Ji-Hoon Cho,Danielle Yi,Angelita G. Utleg,Xuefeng Fang,Dustin E. Schones,Keji Zhao,Gilbert S. Omenn,Leroy Hood +12 more
TL;DR: The data provide a valuable data set in understanding the molecular basis for growth inhibition response program of the AR in prostate cancer cells, which can be exploited for developing novel prostate cancer therapeutic strategies.
Journal ArticleDOI
Landscape of the SOX2 protein–protein interactome
Xuefeng Fang,Jae Geun Yoon,Lisha Li,Yihsuan S. Tsai,Shu Zheng,Leroy Hood,David R. Goodlett,Gregory Foltz,Biaoyang Lin +8 more
TL;DR: Gene ontology analysis revealed that the SOX2 interactome was enriched for GO terms GO:0030529 ribonucleoprotein complex and GO:0004386 helicase activity, suggesting a possible role forSOX2 in post‐transcriptional regulation in addition to its function as a transcription factor.
Journal ArticleDOI
ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers.
Xuefeng Fang,Wei Yu,Lisha Li,Jiaofang Shao,Na Zhao,Qiyun Chen,Zhiyun Ye,Sheng-Cai Lin,Shu Zheng,Biaoyang Lin,Biaoyang Lin +10 more
TL;DR: An integrated expression profiling and ChIP-seq analysis show that SOX2 is involved in the BMP signaling pathway, steroid metabolic process, histone modifications, and many receptor-mediated signaling pathways such as IGF1R and ITPR2 (Inositol 1,4,5-triphosphate receptor, type 2).
Journal ArticleDOI
SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axis
Jing Zhang,Jing Zhang,Huawei Jiang,Huawei Jiang,Jiaofang Shao,Ruifang Mao,Jie Liu,Yingying Ma,Xuefeng Fang,Na Zhao,Shu Zheng,Biaoyang Lin,Biaoyang Lin,Biaoyang Lin +13 more
TL;DR: Gene expression profiling and subsequent gene ontology analysis showed that SOX4 influenced several key pathways including the Wnt/ beta-catenin and TGF-beta signaling pathways.