H
Hiroshi Kurosu
Researcher at Jichi Medical University
Publications - 34
Citations - 7990
Hiroshi Kurosu is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Klotho & Fibroblast growth factor. The author has an hindex of 21, co-authored 31 publications receiving 7157 citations. Previous affiliations of Hiroshi Kurosu include Nagasaki University & University of Texas Southwestern Medical Center.
Papers
More filters
Journal ArticleDOI
Suppression of Aging in Mice by the Hormone Klotho
Hiroshi Kurosu,Masaya Yamamoto,Jeremy D. Clark,Johanne Pastor,Animesh Nandi,Prem Gurnani,Owen P. McGuinness,Hirotaka Chikuda,Masayuki Yamaguchi,Hiroshi Kawaguchi,Iichiro Shimomura,Yoshiharu Takayama,Joachim Herz,C. Ronald Kahn,Kevin P. Rosenblatt,Makoto Kuro-o +15 more
TL;DR: It is shown that overexpression of Klotho in mice extends life span and it is suggested that Klotha-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties.
Journal ArticleDOI
Regulation of Fibroblast Growth Factor-23 Signaling by Klotho
Hiroshi Kurosu,Yasushi Ogawa,Masayoshi Miyoshi,Masaya Yamamoto,Animesh Nandi,Kevin P. Rosenblatt,Michel Baum,Susan C. Schiavi,Ming Chang Hu,Orson W. Moe,Makoto Kuro-o +10 more
TL;DR: It is shown that Klotho protein directly binds to multiple FGF receptors (FGFRs) and significantly enhanced the ability of FGF23 to induce phosphorylation of F GF receptor substrate and ERK in various types of cells.
Journal ArticleDOI
Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21
Hiroshi Kurosu,Mihwa Choi,Yasushi Ogawa,Addie S. Dickson,Regina Goetz,Anna V. Eliseenkova,Moosa Mohammadi,Kevin P. Rosenblatt,Steven A. Kliewer,Makoto Kuro-o +9 more
TL;DR: It is demonstrated that Klotho and βKlotho, homologous single-pass transmembrane proteins that bind to FGFRs, are required for metabolic activity of FGF23 and FGF21, respectively.
Journal ArticleDOI
Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.
Klementina Fon Tacer,Angie L. Bookout,Xunshan Ding,Hiroshi Kurosu,George B. John,Lei Wang,Regina Goetz,Moosa Mohammadi,Makoto Kuro-o,David J. Mangelsdorf,Steven A. Kliewer +10 more
TL;DR: This FGF atlas provides an important resource for guiding future studies to elucidate the physiological functions of FGFs in adult animals and shows that the most recently identified Klotho family member, Lactase-like, is highly and selectively expressed in brown adipose tissue and eye and can function as an additional coreceptor for FGF19.
Journal ArticleDOI
Regulation of oxidative stress by the anti-aging hormone klotho
Masaya Yamamoto,Jeremy D. Clark,Johanne Pastor,Prem Gurnani,Animesh Nandi,Hiroshi Kurosu,Masayoshi Miyoshi,Yasushi Ogawa,Diego H. Castrillon,Kevin P. Rosenblatt,Makoto Kuro-o +10 more
TL;DR: It is shown that Klotho protein increases resistance to oxidative stress at the cellular and organismal level in mammals and potentially contributes to the anti-aging properties of klotho.