Xuran Wang

TL;DR: A new method for estimating cell type proportions from bulk tissue RNA-seq data guided by multi-subject single-cell expression reference, which enables the characterization of cellular heterogeneity of complex tissues for understanding of disease mechanisms.

TL;DR: It is demonstrated that APOE and TREM2 risk variants are associated with a significant reduction in CD163-positive amyloid-responsive microglia, highlighting the diverse microglial response in AD and underscore how genetic risk factors influence cellular responses to underlying pathologies.

TL;DR: Tau-positive pathology represents a significant risk to survival in FTLD, whereas tau-negative pathology is associated with a longer survival time when clinical MND is excluded.

TL;DR: An approach to sensitivity analysis for the IV method is presented which examines the sensitivity of inferences to violations of IV validity and is based on extending the Anderson-Rubin test and is valid regardless of the strength of the instrument.

TL;DR: One-Seq as discussed by the authors uses OligoNucleotide Enrichment and sequencing (ONE-seq) to identify off-target sites of gene editors in human cells.