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Xuyu Qian
Researcher at Johns Hopkins University School of Medicine
Publications - 22
Citations - 5355
Xuyu Qian is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Neurogenesis & Medicine. The author has an hindex of 14, co-authored 18 publications receiving 3812 citations. Previous affiliations of Xuyu Qian include Johns Hopkins University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
Xuyu Qian,Ha Nam Nguyen,Mingxi M. Song,Christopher Hadiono,Sarah C. Ogden,Christy Hammack,Bing Yao,Gregory R. Hamersky,Fadi Jacob,Chun Zhong,Ki Jun Yoon,William J. Jeang,Li Lin,Yujing Li,Jai Thakor,Daniel A. Berg,Ce Zhang,Eunchai Kang,Michael Chickering,David W. Nauen,Cheng-Ying Ho,Cheng-Ying Ho,Zhexing Wen,Kimberly M. Christian,Pei Yong Shi,Brady J. Maher,Hao Wu,Peng Jin,Hengli Tang,Hongjun Song,Guo Li Ming +30 more
TL;DR: A miniaturized spinning bioreactor (SpinΩ) is developed to generate forebrain-specific organoids from human iPSCs that recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and, notably, a distinct human-specific outer radial glia cell layer.
Journal ArticleDOI
Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Hengli Tang,Christy Hammack,Sarah C. Ogden,Zhexing Wen,Xuyu Qian,Yujing Li,Bing Yao,Jaehoon Shin,Feiran Zhang,Emily M. Lee,Kimberly M. Christian,Ruth Didier,Peng Jin,Hongjun Song,Guo Li Ming +14 more
TL;DR: It is shown that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficiently infects human neural progenitor cells (hNPCs) derived from induced pluripotent stem cells, identified as a direct ZikV target, and reveals transcriptional dysregulation, notably of cell-cycle-related pathways.
Journal ArticleDOI
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
Miao Xu,Emily M. Lee,Zhexing Wen,Yichen Cheng,Wei Kai Huang,Xuyu Qian,Julia Tcw,Jennifer Kouznetsova,Sarah C. Ogden,Christy Hammack,Fadi Jacob,Ha Nam Nguyen,Misha Itkin,Catherine Hanna,Paul Shinn,Chase Allen,Samuel G. Michael,Anton Simeonov,Wenwei Huang,Kimberly M. Christian,Alison Goate,Kristen J. Brennand,Ruili Huang,Menghang Xia,Guo Li Ming,Wei Zheng,Hongjun Song,Hengli Tang +27 more
TL;DR: A pan-caspase inhibitor, emricasan, inhibited ZIKV-induced increases in caspase-3 activity and protected human cortical neural progenitors in both monolayer and three-dimensional organoid cultures, and combination treatments using one compound from each category (neuroprotective and antiviral) further increased protection of human neural progensitors and astrocytes from ZIKv-induced cell death.
Journal ArticleDOI
A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity
Fadi Jacob,Fadi Jacob,Ryan D Salinas,Daniel Y. Zhang,Phuong T.T. Nguyen,Jordan G. Schnoll,Samuel Zheng Hao Wong,Samuel Zheng Hao Wong,Radhika Thokala,Saad Sheikh,Deeksha Saxena,Stefan Prokop,Di-ao Liu,Xuyu Qian,Xuyu Qian,Dmitriy Petrov,Timothy H. Lucas,H. Isaac Chen,H. Isaac Chen,Jay F. Dorsey,Kimberly M. Christian,Zev A. Binder,MacLean Nasrallah,Steven Brem,Donald M. O'Rourke,Guo Li Ming,Hongjun Song +26 more
TL;DR: Methods for generating and biobanking patient-derived glioblastoma organoids (GBOs) that recapitulate the histological features, cellular diversity, gene expression, and mutational profiles of their corresponding parental tumors are reported.
Journal ArticleDOI
Brain organoids: advances, applications and challenges.
TL;DR: Recent advances in the development of brain organoid methodologies are summarized and their potential applications as model systems for understanding disease states as well as normal brain development across species are highlighted.