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Yael Zermati
Researcher at Paris Descartes University
Publications - 26
Citations - 3631
Yael Zermati is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Erythropoiesis & Cellular differentiation. The author has an hindex of 20, co-authored 26 publications receiving 3387 citations. Previous affiliations of Yael Zermati include University of Paris & Necker-Enfants Malades Hospital.
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Journal ArticleDOI
Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties.
TL;DR: The depletion or inhibition of HSP27 and HS70 frequently reduces the size of the tumors and even can cause their complete involution (for HSP70).
Journal ArticleDOI
Caspase Activation Is Required for Terminal Erythroid Differentiation
Yael Zermati,Carmen Garrido,Sophie Amsellem,Serge Fishelson,Didier Bouscary,Françoise Valensi,Bruno Varet,Bruno Varet,Eric Solary,Olivier Hermine,Olivier Hermine +10 more
TL;DR: It is shown that caspase inhibitors arrest the maturation of human erythroid progenitors at early stages of differentiation, before nucleus and chromatin condensation, which indicates a new function for caspases as key proteases in the process of erythroblast differentiation.
Journal ArticleDOI
Platelet formation is the consequence of caspase activation within megakaryocytes
Stéphane de Botton,Siham Sabri,Eric Daugas,Yael Zermati,Jacques Emmanuel Guidotti,Olivier Hermine,Guido Kroemer,William Vainchenker,Najet Debili +8 more
TL;DR: It is concluded that proplatelet formation is regulated by a caspase activation limited to only some cellular compartments.
Journal ArticleDOI
Specific involvement of caspases in the differentiation of monocytes into macrophages.
Olivier Sordet,Cédric Rébé,Cédric Rébé,Cédric Rébé,Stéphanie Plenchette,Stéphanie Plenchette,Stéphanie Plenchette,Yael Zermati,Yael Zermati,Yael Zermati,Olivier Hermine,Olivier Hermine,Olivier Hermine,William Vainchenker,William Vainchenker,William Vainchenker,Carmen Garrido,Carmen Garrido,Carmen Garrido,Eric Solary,Eric Solary,Eric Solary,Laurence Dubrez-Daloz,Laurence Dubrez-Daloz,Laurence Dubrez-Daloz +24 more
TL;DR: It is shown that several caspases are activated in human peripheral blood monocytes whose differentiation into macrophages is induced by macrophage colony-stimulating factor (M-CSF).
Journal ArticleDOI
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
Jean-Antoine Ribeil,Yael Zermati,Yael Zermati,Julie Vandekerckhove,Séverine Cathelin,Joelle Kersual,Michael Dussiot,Séverine Coulon,Ivan C. Moura,Ann Zeuner,Thomas Kirkegaard-Sørensen,Bruno Varet,Eric Solary,Carmen Garrido,Olivier Hermine +14 more
TL;DR: During differentiation, but not during apoptosis, the chaperone protein Hsp70 protects GATA-1 from caspase-mediated proteolysis, and in erythroid precursors undergoing terminal differentiation, HSp70 prevents active casp enzyme-3 from cleaving Gata-1 and inducing apoptosis.