M
Michael Dussiot
Researcher at University of Paris
Publications - 76
Citations - 2634
Michael Dussiot is an academic researcher from University of Paris. The author has contributed to research in topics: Erythropoiesis & Medicine. The author has an hindex of 20, co-authored 63 publications receiving 2022 citations. Previous affiliations of Michael Dussiot include Sorbonne & French Institute of Health and Medical Research.
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Journal ArticleDOI
Macrophage Plasticity in Experimental Atherosclerosis
Jamila Khallou-Laschet,Aditi Varthaman,Giulia Fornasa,Caroline Compain,Anh Thu Gaston,Marc Clement,Michael Dussiot,Olivier Levillain,Stéphanie Graff-Dubois,Stéphanie Graff-Dubois,Antonino Nicoletti,Giuseppina Caligiuri +11 more
TL;DR: The study suggests that interventional tools able to revert the MØ infiltrate towards the M2 phenotype may exert an atheroprotective action.
Journal ArticleDOI
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Michael Dussiot,Thiago Trovati Maciel,Aurélie Fricot,Céline Chartier,Olivier Negre,Joel Veiga,Damien Grapton,Etienne Paubelle,Emmanuel Payen,Yves Beuzard,Philippe Leboulch,Jean-Antoine Ribeil,Jean-Benoît Arlet,Francine Côté,Geneviève Courtois,Yelena Ginzburg,Thomas O. Daniel,Rajesh Chopra,Victoria Sung,Olivier Hermine,Ivan C. Moura +20 more
TL;DR: Observations suggest that ActRIIA ligand traps may have therapeutic relevance in β-thalassemia by suppressing the deleterious effects of GDF11, a cytokine which blocks terminal erythroid maturation through an autocrine amplification loop involving oxidative stress and α-globin precipitation.
Journal ArticleDOI
Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1
Jean-Antoine Ribeil,Yael Zermati,Yael Zermati,Julie Vandekerckhove,Séverine Cathelin,Joelle Kersual,Michael Dussiot,Séverine Coulon,Ivan C. Moura,Ann Zeuner,Thomas Kirkegaard-Sørensen,Bruno Varet,Eric Solary,Carmen Garrido,Olivier Hermine +14 more
TL;DR: During differentiation, but not during apoptosis, the chaperone protein Hsp70 protects GATA-1 from caspase-mediated proteolysis, and in erythroid precursors undergoing terminal differentiation, HSp70 prevents active casp enzyme-3 from cleaving Gata-1 and inducing apoptosis.
Journal ArticleDOI
Comprehensive Proteomic Analysis of Human Erythropoiesis
Emilie-Fleur Gautier,Sarah Ducamp,Marjorie Leduc,Virginie Salnot,François Guillonneau,Michael Dussiot,John Hale,Marie-Catherine Giarratana,Anna Raimbault,Luc Douay,Catherine Lacombe,Narla Mohandas,Frédérique Verdier,Yael Zermati,Patrick Mayeux +14 more
TL;DR: This study provides the absolute quantification of protein expression during a complex cellular differentiation process in humans, and it establishes a framework for future studies of disordered erythropoiesis.
Journal ArticleDOI
Type I interferon-mediated autoinflammation due to DNase II deficiency
Mathieu P Rodero,Alessandra Tesser,Eva Bartok,Gillian I. Rice,Erika Della Mina,Marine Depp,Benoit Beitz,Vincent Bondet,Vincent Bondet,Nicolas Cagnard,Darragh Duffy,Darragh Duffy,Michael Dussiot,Marie-Louise Frémond,Marco Gattorno,Flavia Guillem,Naoki Kitabayashi,Fabrice Porcheray,Frédéric Rieux-Laucat,Frédéric Rieux-Laucat,Luis Seabra,Carolina Uggenti,Stefano Volpi,Leo A. H. Zeef,Marie Alexandra Alyanakian,Jacques Beltrand,Jacques Beltrand,Anna Monica Bianco,Nathalie Boddaert,Nathalie Boddaert,Chantal Brouzes,Sophie Candon,Roberta Caorsi,Marina Charbit,Monique Fabre,Flavio Faletra,Muriel Girard,Muriel Girard,Annie Harroche,Evelyn Hartmann,Evelyn Hartmann,Dominique Lasne,Dominique Lasne,Annalisa Marcuzzi,Bénédicte Neven,Bénédicte Neven,Bénédicte Neven,Patrick Nitschke,Tiffany Pascreau,Tiffany Pascreau,Serena Pastore,Capucine Picard,Paolo Picco,Elisa Piscianz,Michel Polak,Michel Polak,Pierre Quartier,Pierre Quartier,Pierre Quartier,Marion Rabant,Gabriele Stocco,Andrea Taddio,Florence Uettwiller,Florence Uettwiller,Florence Uettwiller,Erica Valencic,Diego Vozzi,Gunther Hartmann,Winfried Barchet,Olivier Hermine,Brigitte Bader-Meunier,Brigitte Bader-Meunier,Alberto Tommasini,Yanick J. Crow +73 more
TL;DR: Loss-of-function mutations in the DNASE2 gene are identified that cause type I interferon-mediated autoinflammation due to enhanced systemicinterferon signaling and are defined as a type I Interferonopathy due to DNase II deficiency in humans.